[1,5]-Hydride Shift-Cyclization <i>versus</i> C(sp<sup>2</sup>)-H Functionalization in the Knoevenagel-Cyclization Domino Reactions of 1,4- and 1,5-Benzoxazepines

[1,5]-Hydride Shift-Cyclization <i>versus</i> C(sp<sup>2</sup>)-H Functionalization in the Knoevenagel-Cyclization Domino Reactions of 1,4- and 1,5-Benzoxazepines

Domino cyclization reactions of <i>N</i>-aryl-1,4- and 1,5-benzoxazepine derivatives involving [1,5]-hydride shift or C(sp<sup>2</sup>)-H functionalization were investigated. Neuroprotective and acetylcholinesterase activities of the products were studied. Domino Knoevenagel-...

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Bibliographic Details
Main Authors: Dóra Szalóki Vargáné, László Tóth, Balázs Buglyó, Attila Kiss-Szikszai, Attila Mándi, Péter Mátyus, Sándor Antus, Yinghan Chen, Dehai Li, Lingxue Tao, Haiyan Zhang, Tibor Kurtán
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Molecules
Subjects:
domino knoevenagel-[1,5]-hydride shift-cyclization
1,4-benzoxazepine
1,5-benzoxazepine
tddft-ecd calculation
acetylcholinesterase inhibitory activity
Online Access:https://www.mdpi.com/1420-3049/25/6/1265

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