Neuroprotective Effects of Exogenous Irisin in Kainic Acid-Induced Status Epilepticus

Neuroprotective Effects of Exogenous Irisin in Kainic Acid-Induced Status Epilepticus

Elevated reactive oxygen species (ROS) level is considered a crucial causative factor for neuronal damage in epilepsy. Irisin has been reported to ameliorate mitochondrial dysfunction and to reduce ROS levels; therefore, in this study, the effect of exogenous irisin on neuronal injury was evaluated...

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Bibliographic Details
Main Authors: Yao Cheng, Yaru Cui, Yujie Zhai, Wenyu Xin, Yan Yu, Jia Liang, Shucui Li, Hongliu Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
irisin
status epilepticus
mitophagy
mitochondrial oxidative stress
neuronal injury
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.738533/full

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