Insights into Penicillium brasilianum Secondary Metabolism and Its Biotechnological Potential

• Main Authors: Jaqueline Moraes Bazioli, Luciana Da Silva Amaral, Taícia Pacheco Fill, Edson Rodrigues-Filho
• Format: Article
• Language: English
• Published: MDPI AG 2017-06-01
• Series: Molecules
• Subjects: Penicillium brasilianum; secondary metabolism; biotransformation; biological activity
• Online Access: http://www.mdpi.com/1420-3049/22/6/858

Over the past few years Penicillium brasilianum has been isolated from many different environmental sources as soil isolates, plant endophytes and onion pathogen. All investigated strains share a great ability to produce bioactive secondary metabolites. Different authors have investigated this great capability and here we summarize the metabolic potential and the biological activities related to P. brasilianum’s metabolites with diverse structures. They include secondary metabolites of an alkaloid nature, i.e., 2,5-diketopiperazines, cyclodepsipeptides, meroterpenoids and polyketides. Penicillium brasilianum is also described as a great source of enzymes with biotechnological application potential, which is also highlighted in this review. Additionally, this review will focus on several aspects of Penicillium brasilianum and interesting genomic insights.