Adoptive transfer of immature myeloid cells lacking NF‐κB p50 (p50‐IMC) impedes the growth of MHC‐matched high‐risk neuroblastoma

Adoptive transfer of immature myeloid cells lacking NF‐κB p50 (p50‐IMC) impedes the growth of MHC‐matched high‐risk neuroblastoma

High‐risk neuroblastomas harbor abundant myeloid cells that suppress antitumor immunity and support tumor growth. Macrophages lacking the inhibitory NF‐κB p50 subunit adopt a pro‐inflammatory phenotype. We now report that murine 9464D neuroblastoma cells, which express high levels of exogenous MYCN,...

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Bibliographic Details
Main Authors: Cheng Cui, Theresa Barberi, Rahul Suresh, Alan D. Friedman
Format: Article
Language:English
Published: Wiley 2021-07-01
Series:Molecular Oncology
Subjects:
adoptive transfer
immunotherapy
macrophages
myeloid cells
neuroblastoma
NF‐κB p50
Online Access:https://doi.org/10.1002/1878-0261.12904

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