Antifungal Effect of Lavender Essential Oil (Lavandula angustifolia) and Clotrimazole on Candida albicans: An In Vitro Study
Background. The treatment of candidiasis infections is an important problem in the health care system. This study aimed to investigate the in vitro effect of lavender essential oil and clotrimazole on isolated C. albicans from vaginal candidiasis. Materials and Methods. In this clinical trial, C. al...
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doaj-7ed15d74c901447dbdf31a3ad3e9551d2020-11-24T21:45:45ZengHindawi LimitedScientifica2090-908X2015-01-01201510.1155/2015/261397261397Antifungal Effect of Lavender Essential Oil (Lavandula angustifolia) and Clotrimazole on Candida albicans: An In Vitro StudyFereshteh Behmanesh0Hajar Pasha1Ali Asghar Sefidgar2Mohsen Taghizadeh3Ali Akbar Moghadamnia4Hajar Adib Rad5Leyla Shirkhani6Department of Midwifery, Faculty of Medicine, Babol University of Medical Sciences, Babol, IranInfertility and Reproductive Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IranDepartment of Parasitology and Microbiology, Babol University of Medical Sciences, Babol, IranResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, IranNeuroscience Research Center, Department of Pharmacology, Babol University of Medical Sciences, Babol, IranInfertility and Reproductive Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IranDepartment of Mycology and Parasitology, Faculty of Medicine, Babol University of Medical Sciences, Babol, IranBackground. The treatment of candidiasis infections is an important problem in the health care system. This study aimed to investigate the in vitro effect of lavender essential oil and clotrimazole on isolated C. albicans from vaginal candidiasis. Materials and Methods. In this clinical trial, C. albicans isolated from the vaginal discharge samples was obtained. Results. The pairwise comparison showed that lavender and clotrimazole had a significant difference; this difference in the lavender group was lower than clotrimazole. But, after 48 hours, there was no difference seen between groups. There was a significant difference between clotrimazole and DMSO groups. Comparing the changes between groups based on the same dilution, at 24 h and 48 h in clotrimazole group, showed a significant difference two times in the fungal cell count that its average during 48 h was less than 24 h. A significant difference was observed between the two periods in lavender group, only at the dilutions of 1/20 and 1/80. The average fungal cell count after 48 h was also lower in lavender group. Conclusions. Given that the lavender has antifungal activity, this can be used as an antifungal agent. However, more clinical studies are necessary to validate its use in candida infection.http://dx.doi.org/10.1155/2015/261397 |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fereshteh Behmanesh Hajar Pasha Ali Asghar Sefidgar Mohsen Taghizadeh Ali Akbar Moghadamnia Hajar Adib Rad Leyla Shirkhani |
spellingShingle |
Fereshteh Behmanesh Hajar Pasha Ali Asghar Sefidgar Mohsen Taghizadeh Ali Akbar Moghadamnia Hajar Adib Rad Leyla Shirkhani Antifungal Effect of Lavender Essential Oil (Lavandula angustifolia) and Clotrimazole on Candida albicans: An In Vitro Study Scientifica |
author_facet |
Fereshteh Behmanesh Hajar Pasha Ali Asghar Sefidgar Mohsen Taghizadeh Ali Akbar Moghadamnia Hajar Adib Rad Leyla Shirkhani |
author_sort |
Fereshteh Behmanesh |
title |
Antifungal Effect of Lavender Essential Oil (Lavandula angustifolia) and Clotrimazole on Candida albicans: An In Vitro Study |
title_short |
Antifungal Effect of Lavender Essential Oil (Lavandula angustifolia) and Clotrimazole on Candida albicans: An In Vitro Study |
title_full |
Antifungal Effect of Lavender Essential Oil (Lavandula angustifolia) and Clotrimazole on Candida albicans: An In Vitro Study |
title_fullStr |
Antifungal Effect of Lavender Essential Oil (Lavandula angustifolia) and Clotrimazole on Candida albicans: An In Vitro Study |
title_full_unstemmed |
Antifungal Effect of Lavender Essential Oil (Lavandula angustifolia) and Clotrimazole on Candida albicans: An In Vitro Study |
title_sort |
antifungal effect of lavender essential oil (lavandula angustifolia) and clotrimazole on candida albicans: an in vitro study |
publisher |
Hindawi Limited |
series |
Scientifica |
issn |
2090-908X |
publishDate |
2015-01-01 |
description |
Background. The treatment of candidiasis infections is an important problem in the health care system. This study aimed to investigate the in vitro effect of lavender essential oil and clotrimazole on isolated C. albicans from vaginal candidiasis. Materials and Methods. In this clinical trial, C. albicans isolated from the vaginal discharge samples was obtained. Results. The pairwise comparison showed that lavender and clotrimazole had a significant difference; this difference in the lavender group was lower than clotrimazole. But, after 48 hours, there was no difference seen between groups. There was a significant difference between clotrimazole and DMSO groups. Comparing the changes between groups based on the same dilution, at 24 h and 48 h in clotrimazole group, showed a significant difference two times in the fungal cell count that its average during 48 h was less than 24 h. A significant difference was observed between the two periods in lavender group, only at the dilutions of 1/20 and 1/80. The average fungal cell count after 48 h was also lower in lavender group. Conclusions. Given that the lavender has antifungal activity, this can be used as an antifungal agent. However, more clinical studies are necessary to validate its use in candida infection. |
url |
http://dx.doi.org/10.1155/2015/261397 |
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