Typical symptoms and not positive reflux-cough correlation predict cure of gastroesophageal reflux disease related chronic cough after laparoscopic fundoplication: a retrospective study

• Main Authors: Dong Chen, Zhonggao Wang, Zhiwei Hu, Yan Liang, Fei Xiao, Jimin Wu
• Format: Article
• Language: English
• Published: BMC 2019-06-01
• Series: BMC Gastroenterology
• Subjects: Gastroesophageal reflux disease; Cough; Fundoplication
• Online Access: http://link.springer.com/article/10.1186/s12876-019-1027-8

Abstract Background The effect of laparoscopic fundoplication on reflux-related chronic cough is unpredictable, the aim of the study is to investigate the predictive effect of positive reflux-cough correlation on the resolution of reflux-related chronic cough after anti-reflux surgery. Methods A 5 years retrospective review was performed. Logistic regression analysis was used to determine the independent predictors on the cure of chronic cough. Results Seventy-nine patients were included in this study, among which chronic cough was cured in 47 (59.5%) and significantly improved in 10 (12.7%) patients. Present of typical symptoms (odds ratio = 6.435,95% confidence interval [CI] = 1.427–29.032, p = 0.015) and number of Reflux episodes (impedance) ≥73 (odds ratio = 0.306, 95% confidence interval [CI] = 0.107–0.874, p = 0.027) were significantly associated with the cure of chronic cough. Conclusions laparoscopic fundoplicaiton is effective for the management of reflux-related chronic cough, particularly with the present of typical symptoms. Trial registration (Trial registration number: ChiCTR1800016444; Trial registration date: June 01, 2018)