Construction and Characterization of 1F5 Chimeric Anti-CD20 Monoclonal Antibodies: An Efficient Splicing by Overlap Extension-polymerase Chain Reaction Technique

Construction and Characterization of 1F5 Chimeric Anti-CD20 Monoclonal Antibodies: An Efficient Splicing by Overlap Extension-polymerase Chain Reaction Technique

Despite the unparalleled success of anti-CD20-targeted immunotherapy, the currently available mAbs are not sufficiently efficacious in the treatment of lymphoma. 1F5 is one of a panel of anti-CD20 mAbs that was used in the B-cell lymphoma serotherapy. Despite the efficacy of murine 1F5 mAbs in lymp...

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Bibliographic Details
Main Authors: Fatemeh Khademi, Pantea Mohammadi, Ali Mostafaei
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2021-04-01
Series:Iranian Journal of Allergy, Asthma and Immunology
Subjects:
CD20
Cell proliferation
Cytotoxicity tests
Monoclonal antibody
Online Access:https://ijaai.tums.ac.ir/index.php/ijaai/article/view/2746

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