Activation of the S100A7/RAGE Pathway by IGF-1 Contributes to Angiogenesis in Breast Cancer

Activation of the S100A7/RAGE Pathway by IGF-1 Contributes to Angiogenesis in Breast Cancer

Background: Breast cancer (BC) mortality is increased among obese and diabetic patients. Both obesity and diabetes are associated with dysregulation of both the IGF-1R and the RAGE (Receptor for Advanced Glycation End Products) pathways, which contribute to complications of these disorders. The alar...

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Bibliographic Details
Main Authors: Maria Grazia Muoio, Marianna Talia, Rosamaria Lappano, Andrew H. Sims, Veronica Vella, Francesca Cirillo, Livia Manzella, Marika Giuliano, Marcello Maggiolini, Antonino Belfiore, Ernestina Marianna De Francesco
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cancers
Subjects:
IGF-1
IGF-1R
S100A7/psoriasin
RAGE
breast tumor microenvironment
tumor angiogenesis
Online Access:https://www.mdpi.com/2072-6694/13/4/621

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