Postsplenectomy mortality in animal model
Objecive: It is well known that splenectomy increases the risk of infections, mainly those caused by encapsulated bacteria. These complications are related to higher mortality and lower survival rates in asplenic individuals. The purpose of this study was to assess the mortality of rats submitted to...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Instituto Israelita de Ensino e Pesquisa Albert Einstein
2008-09-01
|
Series: | Einstein (São Paulo) |
Subjects: | |
Online Access: | http://www.einstein.br/revista/arquivos/PDF/782-Einsteinv6n2p151-4.pdf |
id |
doaj-7ee418d6f1e143d3b7f4a09487de294b |
---|---|
record_format |
Article |
spelling |
doaj-7ee418d6f1e143d3b7f4a09487de294b2020-11-25T01:19:26ZengInstituto Israelita de Ensino e Pesquisa Albert EinsteinEinstein (São Paulo)1679-45082008-09-0162151154Postsplenectomy mortality in animal model Andy PetroianuHeather HauterDaniel Adonai Machado CaldeiraRenata Figueiredo RochaLuiz Ronaldo AlbertiObjecive: It is well known that splenectomy increases the risk of infections, mainly those caused by encapsulated bacteria. These complications are related to higher mortality and lower survival rates in asplenic individuals. The purpose of this study was to assess the mortality of rats submitted to total splenectomy. Methods: this is an experimental study. Thirty-four rats were divided into two groups: Group 1 (n = 14): control animals, submitted only to laparotomy; Group 2 (n = 20): animals submitted to splenectomy. Both groups were subdivided into two subgroups: Subgroup A, male rats, and Subgroup B, female rats. The animals were observed during a 90-day period to assess their mortality. Rresults: The mortality of animals in Group 2 was 80% for males and 30% for females. No deaths occurred among the animals of Group 1. The splenectomized males had significantly higher mortality rates than the splenectomized females (p = 0.034). Cconclusions: According to results of this study, total splenectomy increases mortality among rats. Murine females demonstrated greater resistance to the asplenic state, and therefore presented lower mortality rates when compared to male rats.http://www.einstein.br/revista/arquivos/PDF/782-Einsteinv6n2p151-4.pdfSplenectomySpleen/surgerySepsisMortalitySex distributionRatsWistar |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Andy Petroianu Heather Hauter Daniel Adonai Machado Caldeira Renata Figueiredo Rocha Luiz Ronaldo Alberti |
spellingShingle |
Andy Petroianu Heather Hauter Daniel Adonai Machado Caldeira Renata Figueiredo Rocha Luiz Ronaldo Alberti Postsplenectomy mortality in animal model Einstein (São Paulo) Splenectomy Spleen/surgery Sepsis Mortality Sex distribution Rats Wistar |
author_facet |
Andy Petroianu Heather Hauter Daniel Adonai Machado Caldeira Renata Figueiredo Rocha Luiz Ronaldo Alberti |
author_sort |
Andy Petroianu |
title |
Postsplenectomy mortality in animal model |
title_short |
Postsplenectomy mortality in animal model |
title_full |
Postsplenectomy mortality in animal model |
title_fullStr |
Postsplenectomy mortality in animal model |
title_full_unstemmed |
Postsplenectomy mortality in animal model |
title_sort |
postsplenectomy mortality in animal model |
publisher |
Instituto Israelita de Ensino e Pesquisa Albert Einstein |
series |
Einstein (São Paulo) |
issn |
1679-4508 |
publishDate |
2008-09-01 |
description |
Objecive: It is well known that splenectomy increases the risk of infections, mainly those caused by encapsulated bacteria. These complications are related to higher mortality and lower survival rates in asplenic individuals. The purpose of this study was to assess the mortality of rats submitted to total splenectomy. Methods: this is an experimental study. Thirty-four rats were divided into two groups: Group 1 (n = 14): control animals, submitted only to laparotomy; Group 2 (n = 20): animals submitted to splenectomy. Both groups were subdivided into two subgroups: Subgroup A, male rats, and Subgroup B, female rats. The animals were observed during a 90-day period to assess their mortality. Rresults: The mortality of animals in Group 2 was 80% for males and 30% for females. No deaths occurred among the animals of Group 1. The splenectomized males had significantly higher mortality rates than the splenectomized females (p = 0.034). Cconclusions: According to results of this study, total splenectomy increases mortality among rats. Murine females demonstrated greater resistance to the asplenic state, and therefore presented lower mortality rates when compared to male rats. |
topic |
Splenectomy Spleen/surgery Sepsis Mortality Sex distribution Rats Wistar |
url |
http://www.einstein.br/revista/arquivos/PDF/782-Einsteinv6n2p151-4.pdf |
work_keys_str_mv |
AT andypetroianu postsplenectomymortalityinanimalmodel AT heatherhauter postsplenectomymortalityinanimalmodel AT danieladonaimachadocaldeira postsplenectomymortalityinanimalmodel AT renatafigueiredorocha postsplenectomymortalityinanimalmodel AT luizronaldoalberti postsplenectomymortalityinanimalmodel |
_version_ |
1725138378618306560 |