The nonconventional MHC class II molecule DM governs diabetes susceptibility in NOD mice.
The spontaneous destruction of insulin producing pancreatic beta cells in non-obese diabetic (NOD) mice provides a valuable model of type 1 diabetes. As in humans, disease susceptibility is controlled by the classical MHC class II genes that guide CD4(+) T cell responses to self and foreign antigens...
Main Authors: | Marc A J Morgan, Pari S S Muller, Arne Mould, Stephen A Newland, Jennifer Nichols, Elizabeth J Robertson, Anne Cooke, Elizabeth K Bikoff |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3572069?pdf=render |
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