A Short History of Skin Grafting in Burns: From the Gold Standard of Autologous Skin Grafting to the Possibilities of Allogeneic Skin Grafting with Immunomodulatory Approaches
Due to groundbreaking and pioneering developments in the last century, significant improvements in the care of burn patients have been achieved. In addition to the still valid therapeutic standard of autologous split-thickness skin grafting, various commercially available skin substitutes are curren...
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doaj-7ef20b443dcf4e40b1490a7732e0ba082021-03-03T00:00:50ZengMDPI AGMedicina1010-660X2021-03-015722522510.3390/medicina57030225A Short History of Skin Grafting in Burns: From the Gold Standard of Autologous Skin Grafting to the Possibilities of Allogeneic Skin Grafting with Immunomodulatory ApproachesFrederik Schlottmann0Vesna Bucan1Peter M. Vogt2Nicco Krezdorn3Department of Plastic, Aesthetic, Hand- and Reconstructive Surgery, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, GermanyDepartment of Plastic, Aesthetic, Hand- and Reconstructive Surgery, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, GermanyDepartment of Plastic, Aesthetic, Hand- and Reconstructive Surgery, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, GermanyDepartment of Plastic, Aesthetic, Hand- and Reconstructive Surgery, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, GermanyDue to groundbreaking and pioneering developments in the last century, significant improvements in the care of burn patients have been achieved. In addition to the still valid therapeutic standard of autologous split-thickness skin grafting, various commercially available skin substitutes are currently available. Significant progress in the field of tissue engineering has led to the development of promising therapeutic approaches. However, scientific advances in the field of allografting and transplant immunology are of great importance. The achievement of various milestones over the past decades has provided thought-provoking impulses in the field of skin allotransplantation. Thus, biologically viable skin allotransplantation is still not a part of the clinical routine. The purpose of this article is to review the achievements in burn surgery with regards to skin allotransplantation in recent years.https://www.mdpi.com/1010-660X/57/3/225burn careallotransplantationskin transplantationskin graftskin substituteimmuno-compatible skin grafts |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Frederik Schlottmann Vesna Bucan Peter M. Vogt Nicco Krezdorn |
spellingShingle |
Frederik Schlottmann Vesna Bucan Peter M. Vogt Nicco Krezdorn A Short History of Skin Grafting in Burns: From the Gold Standard of Autologous Skin Grafting to the Possibilities of Allogeneic Skin Grafting with Immunomodulatory Approaches Medicina burn care allotransplantation skin transplantation skin graft skin substitute immuno-compatible skin grafts |
author_facet |
Frederik Schlottmann Vesna Bucan Peter M. Vogt Nicco Krezdorn |
author_sort |
Frederik Schlottmann |
title |
A Short History of Skin Grafting in Burns: From the Gold Standard of Autologous Skin Grafting to the Possibilities of Allogeneic Skin Grafting with Immunomodulatory Approaches |
title_short |
A Short History of Skin Grafting in Burns: From the Gold Standard of Autologous Skin Grafting to the Possibilities of Allogeneic Skin Grafting with Immunomodulatory Approaches |
title_full |
A Short History of Skin Grafting in Burns: From the Gold Standard of Autologous Skin Grafting to the Possibilities of Allogeneic Skin Grafting with Immunomodulatory Approaches |
title_fullStr |
A Short History of Skin Grafting in Burns: From the Gold Standard of Autologous Skin Grafting to the Possibilities of Allogeneic Skin Grafting with Immunomodulatory Approaches |
title_full_unstemmed |
A Short History of Skin Grafting in Burns: From the Gold Standard of Autologous Skin Grafting to the Possibilities of Allogeneic Skin Grafting with Immunomodulatory Approaches |
title_sort |
short history of skin grafting in burns: from the gold standard of autologous skin grafting to the possibilities of allogeneic skin grafting with immunomodulatory approaches |
publisher |
MDPI AG |
series |
Medicina |
issn |
1010-660X |
publishDate |
2021-03-01 |
description |
Due to groundbreaking and pioneering developments in the last century, significant improvements in the care of burn patients have been achieved. In addition to the still valid therapeutic standard of autologous split-thickness skin grafting, various commercially available skin substitutes are currently available. Significant progress in the field of tissue engineering has led to the development of promising therapeutic approaches. However, scientific advances in the field of allografting and transplant immunology are of great importance. The achievement of various milestones over the past decades has provided thought-provoking impulses in the field of skin allotransplantation. Thus, biologically viable skin allotransplantation is still not a part of the clinical routine. The purpose of this article is to review the achievements in burn surgery with regards to skin allotransplantation in recent years. |
topic |
burn care allotransplantation skin transplantation skin graft skin substitute immuno-compatible skin grafts |
url |
https://www.mdpi.com/1010-660X/57/3/225 |
work_keys_str_mv |
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