Chronic Gastritis Is Associated with a Decreased High-Density Lipid Level: Histological Features of Gastritis Based on the Updated Sydney System
Chronic gastritis could activate a systemic inflammatory response that could result in adverse lipid profiles. To determine the severity of chronic gastritis, <i>Helicobacter pylori</i> (HP), mononuclear cell (lymphocytes and plasma cells), and neutrophil scores were assessed on the basi...
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doaj-7ef331aaa8fb44c497be8d5eeaa0685a2020-11-25T03:44:44ZengMDPI AGJournal of Clinical Medicine2077-03832020-06-0191856185610.3390/jcm9061856Chronic Gastritis Is Associated with a Decreased High-Density Lipid Level: Histological Features of Gastritis Based on the Updated Sydney SystemDong-Hoon Kim0Byoung Kwan Son1Kyueng-Whan Min2Sang Kuk Han3Ji Ung Na4Pil Cho Choi5Hack-Lyoung Kim6Mi Jung Kwon7Young Ha Oh8Woon Yong Jung9Ji-Yong Moon10Sangmo Hong11Ki-Wook Oh12Young Seo Kim13Departments of Pathology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, KoreaDepartment of Internal Medicine, Eulji Hospital, Eulji University School of Medicine, Seoul 01830, KoreaDepartment of Pathology, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri-si, Gyeonggi-do 11923, KoreaDepartments of Emergency Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, KoreaDepartments of Emergency Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, KoreaDepartments of Emergency Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, KoreaDivision of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Boramae Medical Center, Seoul 07061, KoreaDepartment of Pathology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang-si, Gyeonggi-do 14068, KoreaDepartment of Pathology, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri-si, Gyeonggi-do 11923, KoreaDepartment of Pathology, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri-si, Gyeonggi-do 11923, KoreaDepartment of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri-si, Gyeonggi-do 11923, KoreaDivision of Endocrinology, Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri-si, Gyeonggi-do 11923, KoreaDepartment of Neurology, Hanyang University College of Medicine, Seoul 04763, KoreaDepartment of Neurology, Hanyang University College of Medicine, Seoul 04763, KoreaChronic gastritis could activate a systemic inflammatory response that could result in adverse lipid profiles. To determine the severity of chronic gastritis, <i>Helicobacter pylori</i> (HP), mononuclear cell (lymphocytes and plasma cells), and neutrophil scores were assessed on the basis of the updated Sydney system (USS), which is widely used for histological grading. The aim of this study was to assess the relationships between gastric histological features and lipid profile levels. This study included 15,322 males and 5929 females who underwent a health checkup and gastric biopsy at the Kangbuk Samsung Medical Center (KBSMC). We analyzed whether the HP, mononuclear cell, and neutrophil grades according to the USS were related to serum leukocyte count, unhealthy behaviors, and lipid profile levels. Gastritis with HP, neutrophils, or moderate to severe mononuclear cells was associated with an elevated serum leukocyte count. A high leukocyte count was related to increased low-density lipoproteins (LDL) and triglycerides/very-low-density lipoprotein (VLDL) and decreased high-density lipoproteins (HDL). In multivariate analyses, chronic gastritis with HP or moderate to severe mononuclear cells was significantly associated with decreased HDL in males, while mononuclear cells were significantly related to decreased HDL in females. Chronic gastritis was associated with an increased systemic inflammatory response, which was associated with unfavorable lipid profiles, especially low HDL levels.https://www.mdpi.com/2077-0383/9/6/1856<i>Helicobacter</i>cholesterolgastritiscardiovascular diseases |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dong-Hoon Kim Byoung Kwan Son Kyueng-Whan Min Sang Kuk Han Ji Ung Na Pil Cho Choi Hack-Lyoung Kim Mi Jung Kwon Young Ha Oh Woon Yong Jung Ji-Yong Moon Sangmo Hong Ki-Wook Oh Young Seo Kim |
spellingShingle |
Dong-Hoon Kim Byoung Kwan Son Kyueng-Whan Min Sang Kuk Han Ji Ung Na Pil Cho Choi Hack-Lyoung Kim Mi Jung Kwon Young Ha Oh Woon Yong Jung Ji-Yong Moon Sangmo Hong Ki-Wook Oh Young Seo Kim Chronic Gastritis Is Associated with a Decreased High-Density Lipid Level: Histological Features of Gastritis Based on the Updated Sydney System Journal of Clinical Medicine <i>Helicobacter</i> cholesterol gastritis cardiovascular diseases |
author_facet |
Dong-Hoon Kim Byoung Kwan Son Kyueng-Whan Min Sang Kuk Han Ji Ung Na Pil Cho Choi Hack-Lyoung Kim Mi Jung Kwon Young Ha Oh Woon Yong Jung Ji-Yong Moon Sangmo Hong Ki-Wook Oh Young Seo Kim |
author_sort |
Dong-Hoon Kim |
title |
Chronic Gastritis Is Associated with a Decreased High-Density Lipid Level: Histological Features of Gastritis Based on the Updated Sydney System |
title_short |
Chronic Gastritis Is Associated with a Decreased High-Density Lipid Level: Histological Features of Gastritis Based on the Updated Sydney System |
title_full |
Chronic Gastritis Is Associated with a Decreased High-Density Lipid Level: Histological Features of Gastritis Based on the Updated Sydney System |
title_fullStr |
Chronic Gastritis Is Associated with a Decreased High-Density Lipid Level: Histological Features of Gastritis Based on the Updated Sydney System |
title_full_unstemmed |
Chronic Gastritis Is Associated with a Decreased High-Density Lipid Level: Histological Features of Gastritis Based on the Updated Sydney System |
title_sort |
chronic gastritis is associated with a decreased high-density lipid level: histological features of gastritis based on the updated sydney system |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2020-06-01 |
description |
Chronic gastritis could activate a systemic inflammatory response that could result in adverse lipid profiles. To determine the severity of chronic gastritis, <i>Helicobacter pylori</i> (HP), mononuclear cell (lymphocytes and plasma cells), and neutrophil scores were assessed on the basis of the updated Sydney system (USS), which is widely used for histological grading. The aim of this study was to assess the relationships between gastric histological features and lipid profile levels. This study included 15,322 males and 5929 females who underwent a health checkup and gastric biopsy at the Kangbuk Samsung Medical Center (KBSMC). We analyzed whether the HP, mononuclear cell, and neutrophil grades according to the USS were related to serum leukocyte count, unhealthy behaviors, and lipid profile levels. Gastritis with HP, neutrophils, or moderate to severe mononuclear cells was associated with an elevated serum leukocyte count. A high leukocyte count was related to increased low-density lipoproteins (LDL) and triglycerides/very-low-density lipoprotein (VLDL) and decreased high-density lipoproteins (HDL). In multivariate analyses, chronic gastritis with HP or moderate to severe mononuclear cells was significantly associated with decreased HDL in males, while mononuclear cells were significantly related to decreased HDL in females. Chronic gastritis was associated with an increased systemic inflammatory response, which was associated with unfavorable lipid profiles, especially low HDL levels. |
topic |
<i>Helicobacter</i> cholesterol gastritis cardiovascular diseases |
url |
https://www.mdpi.com/2077-0383/9/6/1856 |
work_keys_str_mv |
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