Single-cell multiomics sequencing reveals the functional regulatory landscape of early embryos

Extensive epigenetic reprogramming occurs during preimplantation embryo development. Here the authors develop a single cell multiomics sequencing technology that enables profiling of genome-wide chromatin accessibility, DNA methylation and RNA expression in the same individual cell and apply this me...

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Main Authors:	Yang Wang, Peng Yuan, Zhiqiang Yan, Ming Yang, Ying Huo, Yanli Nie, Xiaohui Zhu, Jie Qiao, Liying Yan
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-02-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-21409-8

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spelling	doaj-7efdae7a7382401c91ad28ab2db63e3d2021-02-23T10:35:33ZengNature Publishing GroupNature Communications2041-17232021-02-0112111410.1038/s41467-021-21409-8Single-cell multiomics sequencing reveals the functional regulatory landscape of early embryosYang Wang0Peng Yuan1Zhiqiang Yan2Ming Yang3Ying Huo4Yanli Nie5Xiaohui Zhu6Jie Qiao7Liying Yan8Beijing Advanced Innovation Center for Genomics, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third HospitalBeijing Advanced Innovation Center for Genomics, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third HospitalBeijing Advanced Innovation Center for Genomics, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third HospitalBeijing Advanced Innovation Center for Genomics, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third HospitalBeijing Advanced Innovation Center for Genomics, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third HospitalBeijing Advanced Innovation Center for Genomics, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third HospitalBeijing Advanced Innovation Center for Genomics, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third HospitalBeijing Advanced Innovation Center for Genomics, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third HospitalBeijing Advanced Innovation Center for Genomics, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third HospitalExtensive epigenetic reprogramming occurs during preimplantation embryo development. Here the authors develop a single cell multiomics sequencing technology that enables profiling of genome-wide chromatin accessibility, DNA methylation and RNA expression in the same individual cell and apply this method to study mouse preimplantation embryos.https://doi.org/10.1038/s41467-021-21409-8
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yang Wang Peng Yuan Zhiqiang Yan Ming Yang Ying Huo Yanli Nie Xiaohui Zhu Jie Qiao Liying Yan
spellingShingle	Yang Wang Peng Yuan Zhiqiang Yan Ming Yang Ying Huo Yanli Nie Xiaohui Zhu Jie Qiao Liying Yan Single-cell multiomics sequencing reveals the functional regulatory landscape of early embryos Nature Communications
author_facet	Yang Wang Peng Yuan Zhiqiang Yan Ming Yang Ying Huo Yanli Nie Xiaohui Zhu Jie Qiao Liying Yan
author_sort	Yang Wang
title	Single-cell multiomics sequencing reveals the functional regulatory landscape of early embryos
title_short	Single-cell multiomics sequencing reveals the functional regulatory landscape of early embryos
title_full	Single-cell multiomics sequencing reveals the functional regulatory landscape of early embryos
title_fullStr	Single-cell multiomics sequencing reveals the functional regulatory landscape of early embryos
title_full_unstemmed	Single-cell multiomics sequencing reveals the functional regulatory landscape of early embryos
title_sort	single-cell multiomics sequencing reveals the functional regulatory landscape of early embryos
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-02-01
description	Extensive epigenetic reprogramming occurs during preimplantation embryo development. Here the authors develop a single cell multiomics sequencing technology that enables profiling of genome-wide chromatin accessibility, DNA methylation and RNA expression in the same individual cell and apply this method to study mouse preimplantation embryos.
url	https://doi.org/10.1038/s41467-021-21409-8
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Single-cell multiomics sequencing reveals the functional regulatory landscape of early embryos

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