Holocord low grade astrocytoma – Role of radical irradiation and chemotherapy

Spinal intradural tumors, especially those extending along the entire length of the spinal cord, termed as ‘holocord’ tumors are uncommon. Most of these are gliomas, with astrocytomas (low grade) predominating in children and ependymomas in adults. Other histologies, though reported, are even rarer....

Full description

Bibliographic Details
Main Authors: Shikha Goyal, Tarun Puri, P.K. Julka
Format: Article
Language:English
Published: SpringerOpen 2015-06-01
Series:Journal of the Egyptian National Cancer Institute
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1110036215000035
id doaj-7f292a2faf9b485cbc049991b18d1482
record_format Article
spelling doaj-7f292a2faf9b485cbc049991b18d14822020-11-25T02:40:32ZengSpringerOpenJournal of the Egyptian National Cancer Institute1110-03622015-06-0127210510810.1016/j.jnci.2015.01.001Holocord low grade astrocytoma – Role of radical irradiation and chemotherapyShikha GoyalTarun PuriP.K. JulkaSpinal intradural tumors, especially those extending along the entire length of the spinal cord, termed as ‘holocord’ tumors are uncommon. Most of these are gliomas, with astrocytomas (low grade) predominating in children and ependymomas in adults. Other histologies, though reported, are even rarer. Management is debatable, with both surgery and radiotherapy of such extensive tumors posing challenges. We describe a case of a 14-year-old girl with holocord astrocytoma extending from cervicomedullary junction till lumbar spine, who recovered full neurological function following radical irradiation of entire spine followed by temozolomide-based chemotherapy. No grade 3/4 bone marrow morbidity was seen. Five years following treatment, she maintained normal neurological function and apparently normal pubertal and skeletal growth despite residual disease visible on imaging. Literature review of existing reports of holocord astrocytomas highlighting management and outcome is presented.http://www.sciencedirect.com/science/article/pii/S1110036215000035Holocord astrocytomaRadiotherapyTemozolomide
collection DOAJ
language English
format Article
sources DOAJ
author Shikha Goyal
Tarun Puri
P.K. Julka
spellingShingle Shikha Goyal
Tarun Puri
P.K. Julka
Holocord low grade astrocytoma – Role of radical irradiation and chemotherapy
Journal of the Egyptian National Cancer Institute
Holocord astrocytoma
Radiotherapy
Temozolomide
author_facet Shikha Goyal
Tarun Puri
P.K. Julka
author_sort Shikha Goyal
title Holocord low grade astrocytoma – Role of radical irradiation and chemotherapy
title_short Holocord low grade astrocytoma – Role of radical irradiation and chemotherapy
title_full Holocord low grade astrocytoma – Role of radical irradiation and chemotherapy
title_fullStr Holocord low grade astrocytoma – Role of radical irradiation and chemotherapy
title_full_unstemmed Holocord low grade astrocytoma – Role of radical irradiation and chemotherapy
title_sort holocord low grade astrocytoma – role of radical irradiation and chemotherapy
publisher SpringerOpen
series Journal of the Egyptian National Cancer Institute
issn 1110-0362
publishDate 2015-06-01
description Spinal intradural tumors, especially those extending along the entire length of the spinal cord, termed as ‘holocord’ tumors are uncommon. Most of these are gliomas, with astrocytomas (low grade) predominating in children and ependymomas in adults. Other histologies, though reported, are even rarer. Management is debatable, with both surgery and radiotherapy of such extensive tumors posing challenges. We describe a case of a 14-year-old girl with holocord astrocytoma extending from cervicomedullary junction till lumbar spine, who recovered full neurological function following radical irradiation of entire spine followed by temozolomide-based chemotherapy. No grade 3/4 bone marrow morbidity was seen. Five years following treatment, she maintained normal neurological function and apparently normal pubertal and skeletal growth despite residual disease visible on imaging. Literature review of existing reports of holocord astrocytomas highlighting management and outcome is presented.
topic Holocord astrocytoma
Radiotherapy
Temozolomide
url http://www.sciencedirect.com/science/article/pii/S1110036215000035
work_keys_str_mv AT shikhagoyal holocordlowgradeastrocytomaroleofradicalirradiationandchemotherapy
AT tarunpuri holocordlowgradeastrocytomaroleofradicalirradiationandchemotherapy
AT pkjulka holocordlowgradeastrocytomaroleofradicalirradiationandchemotherapy
_version_ 1724781017657507840