Holocord low grade astrocytoma – Role of radical irradiation and chemotherapy
Spinal intradural tumors, especially those extending along the entire length of the spinal cord, termed as ‘holocord’ tumors are uncommon. Most of these are gliomas, with astrocytomas (low grade) predominating in children and ependymomas in adults. Other histologies, though reported, are even rarer....
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
SpringerOpen
2015-06-01
|
Series: | Journal of the Egyptian National Cancer Institute |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1110036215000035 |
id |
doaj-7f292a2faf9b485cbc049991b18d1482 |
---|---|
record_format |
Article |
spelling |
doaj-7f292a2faf9b485cbc049991b18d14822020-11-25T02:40:32ZengSpringerOpenJournal of the Egyptian National Cancer Institute1110-03622015-06-0127210510810.1016/j.jnci.2015.01.001Holocord low grade astrocytoma – Role of radical irradiation and chemotherapyShikha GoyalTarun PuriP.K. JulkaSpinal intradural tumors, especially those extending along the entire length of the spinal cord, termed as ‘holocord’ tumors are uncommon. Most of these are gliomas, with astrocytomas (low grade) predominating in children and ependymomas in adults. Other histologies, though reported, are even rarer. Management is debatable, with both surgery and radiotherapy of such extensive tumors posing challenges. We describe a case of a 14-year-old girl with holocord astrocytoma extending from cervicomedullary junction till lumbar spine, who recovered full neurological function following radical irradiation of entire spine followed by temozolomide-based chemotherapy. No grade 3/4 bone marrow morbidity was seen. Five years following treatment, she maintained normal neurological function and apparently normal pubertal and skeletal growth despite residual disease visible on imaging. Literature review of existing reports of holocord astrocytomas highlighting management and outcome is presented.http://www.sciencedirect.com/science/article/pii/S1110036215000035Holocord astrocytomaRadiotherapyTemozolomide |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shikha Goyal Tarun Puri P.K. Julka |
spellingShingle |
Shikha Goyal Tarun Puri P.K. Julka Holocord low grade astrocytoma – Role of radical irradiation and chemotherapy Journal of the Egyptian National Cancer Institute Holocord astrocytoma Radiotherapy Temozolomide |
author_facet |
Shikha Goyal Tarun Puri P.K. Julka |
author_sort |
Shikha Goyal |
title |
Holocord low grade astrocytoma – Role of radical irradiation and chemotherapy |
title_short |
Holocord low grade astrocytoma – Role of radical irradiation and chemotherapy |
title_full |
Holocord low grade astrocytoma – Role of radical irradiation and chemotherapy |
title_fullStr |
Holocord low grade astrocytoma – Role of radical irradiation and chemotherapy |
title_full_unstemmed |
Holocord low grade astrocytoma – Role of radical irradiation and chemotherapy |
title_sort |
holocord low grade astrocytoma – role of radical irradiation and chemotherapy |
publisher |
SpringerOpen |
series |
Journal of the Egyptian National Cancer Institute |
issn |
1110-0362 |
publishDate |
2015-06-01 |
description |
Spinal intradural tumors, especially those extending along the entire length of the spinal cord, termed as ‘holocord’ tumors are uncommon. Most of these are gliomas, with astrocytomas (low grade) predominating in children and ependymomas in adults. Other histologies, though reported, are even rarer. Management is debatable, with both surgery and radiotherapy of such extensive tumors posing challenges. We describe a case of a 14-year-old girl with holocord astrocytoma extending from cervicomedullary junction till lumbar spine, who recovered full neurological function following radical irradiation of entire spine followed by temozolomide-based chemotherapy. No grade 3/4 bone marrow morbidity was seen. Five years following treatment, she maintained normal neurological function and apparently normal pubertal and skeletal growth despite residual disease visible on imaging. Literature review of existing reports of holocord astrocytomas highlighting management and outcome is presented. |
topic |
Holocord astrocytoma Radiotherapy Temozolomide |
url |
http://www.sciencedirect.com/science/article/pii/S1110036215000035 |
work_keys_str_mv |
AT shikhagoyal holocordlowgradeastrocytomaroleofradicalirradiationandchemotherapy AT tarunpuri holocordlowgradeastrocytomaroleofradicalirradiationandchemotherapy AT pkjulka holocordlowgradeastrocytomaroleofradicalirradiationandchemotherapy |
_version_ |
1724781017657507840 |