Knudson to embryo selection: A story of the genetics of retinoblastoma
Retinoblastoma, the most common primary intraocular malignancy of the young, is a prototype hereditary cancer. Due to its fairly predictable Mendelian inheritance, easily examinable tumors, and early age of presentation, RB has served as the most extensively studied model for genetics in cancer. The...
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Wolters Kluwer Medknow Publications
2018-01-01
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doaj-7f2a0f08484b40ef85149f2e216376212020-11-24T23:31:29ZengWolters Kluwer Medknow PublicationsTaiwan Journal of Ophthalmology2211-50562211-50722018-01-018419620410.4103/tjo.tjo_37_18Knudson to embryo selection: A story of the genetics of retinoblastomaVrushali AthavaleVikas KhetanRetinoblastoma, the most common primary intraocular malignancy of the young, is a prototype hereditary cancer. Due to its fairly predictable Mendelian inheritance, easily examinable tumors, and early age of presentation, RB has served as the most extensively studied model for genetics in cancer. The genetic strides in RB have progressed at an exponential rate since the 1970s. The highly morbid, reasonably curable and distinctly predictable inheritance pattern of RB; not to mention its propensity to affect our young, forms the basis of aggressively encouraging genetic diagnosis in all patients of RB. In this article, we present the basic and clinically relevant concepts of the genetics retinoblastoma.http://www.e-tjo.org/article.asp?issn=2211-5056;year=2018;volume=8;issue=4;spage=196;epage=204;aulast=AthavaleGenetic counsellinggenetics of retinoblastomaMYCN mutation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Vrushali Athavale Vikas Khetan |
spellingShingle |
Vrushali Athavale Vikas Khetan Knudson to embryo selection: A story of the genetics of retinoblastoma Taiwan Journal of Ophthalmology Genetic counselling genetics of retinoblastoma MYCN mutation |
author_facet |
Vrushali Athavale Vikas Khetan |
author_sort |
Vrushali Athavale |
title |
Knudson to embryo selection: A story of the genetics of retinoblastoma |
title_short |
Knudson to embryo selection: A story of the genetics of retinoblastoma |
title_full |
Knudson to embryo selection: A story of the genetics of retinoblastoma |
title_fullStr |
Knudson to embryo selection: A story of the genetics of retinoblastoma |
title_full_unstemmed |
Knudson to embryo selection: A story of the genetics of retinoblastoma |
title_sort |
knudson to embryo selection: a story of the genetics of retinoblastoma |
publisher |
Wolters Kluwer Medknow Publications |
series |
Taiwan Journal of Ophthalmology |
issn |
2211-5056 2211-5072 |
publishDate |
2018-01-01 |
description |
Retinoblastoma, the most common primary intraocular malignancy of the young, is a prototype hereditary cancer. Due to its fairly predictable Mendelian inheritance, easily examinable tumors, and early age of presentation, RB has served as the most extensively studied model for genetics in cancer. The genetic strides in RB have progressed at an exponential rate since the 1970s. The highly morbid, reasonably curable and distinctly predictable inheritance pattern of RB; not to mention its propensity to affect our young, forms the basis of aggressively encouraging genetic diagnosis in all patients of RB. In this article, we present the basic and clinically relevant concepts of the genetics retinoblastoma. |
topic |
Genetic counselling genetics of retinoblastoma MYCN mutation |
url |
http://www.e-tjo.org/article.asp?issn=2211-5056;year=2018;volume=8;issue=4;spage=196;epage=204;aulast=Athavale |
work_keys_str_mv |
AT vrushaliathavale knudsontoembryoselectionastoryofthegeneticsofretinoblastoma AT vikaskhetan knudsontoembryoselectionastoryofthegeneticsofretinoblastoma |
_version_ |
1725537739977261056 |