Frontiers of MicroRNA Signature in Non-small Cell Lung Cancer

• Main Authors: Xinping Zhu, Masahisa Kudo, Xiangjie Huang, Hehuan Sui, Haishan Tian, Carlo M. Croce, Ri Cui
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2021-04-01
• Series: Frontiers in Cell and Developmental Biology
• Subjects: NSCLC; miRNA; miRNA therapeutics; circulatory miRNAs; miRNA dysregulation
• Online Access: https://www.frontiersin.org/articles/10.3389/fcell.2021.643942/full

Lung cancer is the leading cause of cancer-related deaths worldwide and non-small cell lung cancer (NSCLC) accounts for more than 80% of all lung cancer cases. Recent advancements in diagnostic tools, surgical treatments, chemotherapies, and molecular targeted therapies that improved the therapeutic efficacy in NSCLC. However, the 5-years relative survival rate of NSCLC is only about 20% due to the inadequate screening methods and late onset of clinical symptoms. Dysregulation of microRNAs (miRNAs) was frequently observed in NSCLC and closely associated with NSCLC development, progression, and metastasis through regulating their target genes. In this review, we provide an updated overview of aberrant miRNA signature in NSCLC, and discuss the possibility of miRNAs becoming a diagnostic and therapeutic tool. We also discuss the possible causes of dysregulated miRNAs in NSCLC.