Unexpected Association of Desacyl-Ghrelin with Physical Activity and Chronic Food Restriction: A Translational Study on Anorexia Nervosa
Anorexia nervosa (AN) is a severe metabopsychiatric disorder characterised by caloric intake restriction and often excessive physical exercise. Our aim is to assess in female AN patients and in a rodent model, the co-evolution of physical activity and potential dysregulation of acyl—(AG) and desacyl...
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doaj-7f4e089c456f47eeb7f0e187392bb82f2020-11-25T03:49:55ZengMDPI AGJournal of Clinical Medicine2077-03832020-08-0192782278210.3390/jcm9092782Unexpected Association of Desacyl-Ghrelin with Physical Activity and Chronic Food Restriction: A Translational Study on Anorexia NervosaPhilibert Duriez0Lauralee Robichon1Roland Dardennes2Guillaume Lavoisy3Dominique Grouselle4Jacques Epelbaum5Nicolas Ramoz6Philip Gorwood7Virginie Tolle8Odile Viltart9Institute of Psychiatry and Neuroscience of Paris (IPNP), Université de Paris, INSERM UMR-S 1266, F-75014 Paris, FranceInstitute of Psychiatry and Neuroscience of Paris (IPNP), Université de Paris, INSERM UMR-S 1266, F-75014 Paris, FranceGHU Paris Psychiatrie et Neurosciences, Hôpital Sainte-Anne, F-75014 Paris, FranceGHU Paris Psychiatrie et Neurosciences, Hôpital Sainte-Anne, F-75014 Paris, FranceInstitute of Psychiatry and Neuroscience of Paris (IPNP), Université de Paris, INSERM UMR-S 1266, F-75014 Paris, FranceInstitute of Psychiatry and Neuroscience of Paris (IPNP), Université de Paris, INSERM UMR-S 1266, F-75014 Paris, FranceInstitute of Psychiatry and Neuroscience of Paris (IPNP), Université de Paris, INSERM UMR-S 1266, F-75014 Paris, FranceInstitute of Psychiatry and Neuroscience of Paris (IPNP), Université de Paris, INSERM UMR-S 1266, F-75014 Paris, FranceInstitute of Psychiatry and Neuroscience of Paris (IPNP), Université de Paris, INSERM UMR-S 1266, F-75014 Paris, FranceInstitute of Psychiatry and Neuroscience of Paris (IPNP), Université de Paris, INSERM UMR-S 1266, F-75014 Paris, FranceAnorexia nervosa (AN) is a severe metabopsychiatric disorder characterised by caloric intake restriction and often excessive physical exercise. Our aim is to assess in female AN patients and in a rodent model, the co-evolution of physical activity and potential dysregulation of acyl—(AG) and desacyl—(DAG) ghrelin plasma concentrations during denutrition and weight recovery. AN inpatients were evaluated at inclusion (T0, <i>n</i> = 29), half—(T1) and total (T2) weight recovery, and one month after discharge (T3, <i>n</i> = 13). C57/Bl6 mice with access to a running wheel, were fed ad libitum or submitted to short—(15 days) or long—(50 days) term quantitative food restriction, followed by refeeding (20 days). In AN patients, AG and DAG rapidly decreased during weight recovery (T0 to T2), AG increased significantly one-month post discharge (T3), but only DAG plasma concentrations at T3 correlated negatively with BMI and positively with physical activity. In mice, AG and DAG both increased during short- and long-term food restriction. After 20 days of ad libitum feeding, DAG was associated to persistence of exercise alteration. The positive association of DAG with physical activity during caloric restriction and after weight recovery questions its role in the adaptation mechanisms to energy deprivation that need to be considered in recovery process in AN.https://www.mdpi.com/2077-0383/9/9/2782restrictive anorexia nervosaweight recoveryanimal modelsacyl-ghrelindesacyl-ghrelinphysical activity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Philibert Duriez Lauralee Robichon Roland Dardennes Guillaume Lavoisy Dominique Grouselle Jacques Epelbaum Nicolas Ramoz Philip Gorwood Virginie Tolle Odile Viltart |
spellingShingle |
Philibert Duriez Lauralee Robichon Roland Dardennes Guillaume Lavoisy Dominique Grouselle Jacques Epelbaum Nicolas Ramoz Philip Gorwood Virginie Tolle Odile Viltart Unexpected Association of Desacyl-Ghrelin with Physical Activity and Chronic Food Restriction: A Translational Study on Anorexia Nervosa Journal of Clinical Medicine restrictive anorexia nervosa weight recovery animal models acyl-ghrelin desacyl-ghrelin physical activity |
author_facet |
Philibert Duriez Lauralee Robichon Roland Dardennes Guillaume Lavoisy Dominique Grouselle Jacques Epelbaum Nicolas Ramoz Philip Gorwood Virginie Tolle Odile Viltart |
author_sort |
Philibert Duriez |
title |
Unexpected Association of Desacyl-Ghrelin with Physical Activity and Chronic Food Restriction: A Translational Study on Anorexia Nervosa |
title_short |
Unexpected Association of Desacyl-Ghrelin with Physical Activity and Chronic Food Restriction: A Translational Study on Anorexia Nervosa |
title_full |
Unexpected Association of Desacyl-Ghrelin with Physical Activity and Chronic Food Restriction: A Translational Study on Anorexia Nervosa |
title_fullStr |
Unexpected Association of Desacyl-Ghrelin with Physical Activity and Chronic Food Restriction: A Translational Study on Anorexia Nervosa |
title_full_unstemmed |
Unexpected Association of Desacyl-Ghrelin with Physical Activity and Chronic Food Restriction: A Translational Study on Anorexia Nervosa |
title_sort |
unexpected association of desacyl-ghrelin with physical activity and chronic food restriction: a translational study on anorexia nervosa |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2020-08-01 |
description |
Anorexia nervosa (AN) is a severe metabopsychiatric disorder characterised by caloric intake restriction and often excessive physical exercise. Our aim is to assess in female AN patients and in a rodent model, the co-evolution of physical activity and potential dysregulation of acyl—(AG) and desacyl—(DAG) ghrelin plasma concentrations during denutrition and weight recovery. AN inpatients were evaluated at inclusion (T0, <i>n</i> = 29), half—(T1) and total (T2) weight recovery, and one month after discharge (T3, <i>n</i> = 13). C57/Bl6 mice with access to a running wheel, were fed ad libitum or submitted to short—(15 days) or long—(50 days) term quantitative food restriction, followed by refeeding (20 days). In AN patients, AG and DAG rapidly decreased during weight recovery (T0 to T2), AG increased significantly one-month post discharge (T3), but only DAG plasma concentrations at T3 correlated negatively with BMI and positively with physical activity. In mice, AG and DAG both increased during short- and long-term food restriction. After 20 days of ad libitum feeding, DAG was associated to persistence of exercise alteration. The positive association of DAG with physical activity during caloric restriction and after weight recovery questions its role in the adaptation mechanisms to energy deprivation that need to be considered in recovery process in AN. |
topic |
restrictive anorexia nervosa weight recovery animal models acyl-ghrelin desacyl-ghrelin physical activity |
url |
https://www.mdpi.com/2077-0383/9/9/2782 |
work_keys_str_mv |
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