The NOTCH-HES-1 axis is involved in promoting Th22 cell differentiation

The NOTCH-HES-1 axis is involved in promoting Th22 cell differentiation

Abstract Background NOTCH signaling has been shown to play a role in the production of interleukin-22 (IL-22) by CD4+ T cells. Multiple T-helper (Th) cell populations secrete IL-22. Th22 (CD4+IL22+IFNγ−IL17A−) cells are a subgroup of CD4+ effector T cells that primarily generate IL-22. The regulator...

Full description

Bibliographic Details
Main Authors: Chong Zeng, Zhongbao Shao, Zibo Wei, Jie Yao, Weidong Wang, Liang Yin, Huixian YangOu, Dan Xiong
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Cellular & Molecular Biology Letters
Subjects:
CD4+ T cells
NOTCH signaling
HES-1
Th22
Differentiation
Online Access:https://doi.org/10.1186/s11658-021-00249-w

Similar Items

Similar Items