Mesenchymal stromal cell-derived extracellular vesicles attenuate lung ischemia-reperfusion injury and enhance reconditioning of donor lungs after circulatory death

Mesenchymal stromal cell-derived extracellular vesicles attenuate lung ischemia-reperfusion injury and enhance reconditioning of donor lungs after circulatory death

Abstract Background Lung ischemia-reperfusion (IR) injury after transplantation as well as acute shortage of suitable donor lungs are two critical issues impacting lung transplant patients. This study investigates the anti-inflammatory and immunomodulatory role of human mesenchymal stromal cells (MS...

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Bibliographic Details
Main Authors: Matthew L. Stone, Yunge Zhao, J. Robert Smith, Mark L. Weiss, Irving L. Kron, Victor E. Laubach, Ashish K. Sharma
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Respiratory Research
Subjects:
Mesenchymal stromal cells
Microvesicles
Ischemia-reperfusion injury
Ex vivo lung perfusion
Donation after circulatory death
Online Access:http://link.springer.com/article/10.1186/s12931-017-0704-9

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