Genome-Wide Association Study of Medication Adherence in Chronic Diseases in the Korean Population
Medication adherence is generally defined as the extent of voluntary cooperation of a patient in taking medicine as prescribed. Adherence to long-term treatment with chronic disease is essential for reducing disease comorbidity and mortality. However, medication non-adherence in chronic disease aver...
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doaj-7f631a5bedd14d4a921942a61843a6392020-11-25T00:10:39ZengKorea Genome OrganizationGenomics & Informatics1598-866X2234-07422014-09-0112312112610.5808/GI.2014.12.3.12194Genome-Wide Association Study of Medication Adherence in Chronic Diseases in the Korean PopulationIncheol Seo0Seong-Il Suh1Min-Ho Suh2Won-Ki Baek3Department of Microbiology, Keimyung University School of Medicine, Daegu 704-701, Korea.Department of Microbiology, Keimyung University School of Medicine, Daegu 704-701, Korea.Department of Microbiology, Keimyung University School of Medicine, Daegu 704-701, Korea.Department of Microbiology, Keimyung University School of Medicine, Daegu 704-701, Korea.Medication adherence is generally defined as the extent of voluntary cooperation of a patient in taking medicine as prescribed. Adherence to long-term treatment with chronic disease is essential for reducing disease comorbidity and mortality. However, medication non-adherence in chronic disease averages 50%. This study was conducted a genome-wide association study to identify the genetic basis of medication adherence. A total of 235 medication non-adherents and 1,067 medication adherents with hypertension or diabetes were used from the Korean Association Resource project data according to the self-reported treatment status of each chronic disease, respectively. We identified four single nucleotide polymorphisms with suggestive genome-wide association. The most significant single nucleotide polymorphism was rs6978712 (chromosome 7, p = 4.87 × 10-7), which is located proximal to the GCC1 gene, which was previously implicated in decision-making capability in drug abusers. Two suggestive single nucleotide polymorphisms were in strong linkage disequilibrium (r2 > 0.8) with rs6978712. Thus, in the aspect of decision-making in adherence behavior, the association between medication adherence and three loci proximal to the GCC1 gene seems worthy of further research. However, to overcome a few limitations in this study, defining the standardized phenotype criteria for self-reported adherence should be performed before replicating association studies.http://genominfo.org/upload/pdf/gni-12-121.pdfchronic diseasegenome-wide association studymedication adherencemedication compliance |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Incheol Seo Seong-Il Suh Min-Ho Suh Won-Ki Baek |
spellingShingle |
Incheol Seo Seong-Il Suh Min-Ho Suh Won-Ki Baek Genome-Wide Association Study of Medication Adherence in Chronic Diseases in the Korean Population Genomics & Informatics chronic disease genome-wide association study medication adherence medication compliance |
author_facet |
Incheol Seo Seong-Il Suh Min-Ho Suh Won-Ki Baek |
author_sort |
Incheol Seo |
title |
Genome-Wide Association Study of Medication Adherence in Chronic Diseases in the Korean Population |
title_short |
Genome-Wide Association Study of Medication Adherence in Chronic Diseases in the Korean Population |
title_full |
Genome-Wide Association Study of Medication Adherence in Chronic Diseases in the Korean Population |
title_fullStr |
Genome-Wide Association Study of Medication Adherence in Chronic Diseases in the Korean Population |
title_full_unstemmed |
Genome-Wide Association Study of Medication Adherence in Chronic Diseases in the Korean Population |
title_sort |
genome-wide association study of medication adherence in chronic diseases in the korean population |
publisher |
Korea Genome Organization |
series |
Genomics & Informatics |
issn |
1598-866X 2234-0742 |
publishDate |
2014-09-01 |
description |
Medication adherence is generally defined as the extent of voluntary cooperation of a patient in taking medicine as prescribed. Adherence to long-term treatment with chronic disease is essential for reducing disease comorbidity and mortality. However, medication non-adherence in chronic disease averages 50%. This study was conducted a genome-wide association study to identify the genetic basis of medication adherence. A total of 235 medication non-adherents and 1,067 medication adherents with hypertension or diabetes were used from the Korean Association Resource project data according to the self-reported treatment status of each chronic disease, respectively. We identified four single nucleotide polymorphisms with suggestive genome-wide association. The most significant single nucleotide polymorphism was rs6978712 (chromosome 7, p = 4.87 × 10-7), which is located proximal to the GCC1 gene, which was previously implicated in decision-making capability in drug abusers. Two suggestive single nucleotide polymorphisms were in strong linkage disequilibrium (r2 > 0.8) with rs6978712. Thus, in the aspect of decision-making in adherence behavior, the association between medication adherence and three loci proximal to the GCC1 gene seems worthy of further research. However, to overcome a few limitations in this study, defining the standardized phenotype criteria for self-reported adherence should be performed before replicating association studies. |
topic |
chronic disease genome-wide association study medication adherence medication compliance |
url |
http://genominfo.org/upload/pdf/gni-12-121.pdf |
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