Lipoprotein Proteomics and Aortic Valve Transcriptomics Identify Biological Pathways Linking Lipoprotein(a) Levels to Aortic Stenosis

Lipoprotein Proteomics and Aortic Valve Transcriptomics Identify Biological Pathways Linking Lipoprotein(a) Levels to Aortic Stenosis

Lipoprotein(a) (Lp(a)) is one of the most important risk factors for the development of calcific aortic valve stenosis (CAVS). However, the mechanisms through which Lp(a) causes CAVS are currently unknown. Our objectives were to characterize the Lp(a) proteome and to identify proteins that may be di...

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Bibliographic Details
Main Authors: Raphaëlle Bourgeois, Jérôme Bourgault, Audrey-Anne Despres, Nicolas Perrot, Jakie Guertin, Arnaud Girard, Patricia L. Mitchell, Clarisse Gotti, Sylvie Bourassa, Corey A. Scipione, Nathalie Gaudreault, Michael B. Boffa, Marlys L. Koschinsky, Philippe Pibarot, Arnaud Droit, Sébastien Thériault, Patrick Mathieu, Yohan Bossé, Benoit J. Arsenault
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Metabolites
Subjects:
lipoprotein(a)
calcific aortic valve stenosis
aortic valve
proteomics
transcriptomics
Online Access:https://www.mdpi.com/2218-1989/11/7/459

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