Clinical Efficacy of Azithromycin as an Adjunctive Therapy to Non-Surgical Periodontal Treatment of Periodontitis: A Systematic Review and Meta-Analysis
Introduction: Over the years, numerous trials have sufficiently documented benefits of adjuvant administration of antibiotics in combination to Scaling and Root Planing (SRP) in treatment of periodontitis. Nevertheless there are justified doubts in respect to antibiotics administration with rega...
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doaj-7f7fc537ef76433db3982906d81eb3ca2020-11-25T03:19:29ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2016-07-01107ZE01ZE0710.7860/JCDR/2016/20176.8115Clinical Efficacy of Azithromycin as an Adjunctive Therapy to Non-Surgical Periodontal Treatment of Periodontitis: A Systematic Review and Meta-AnalysisAntonio Renatus0Jörg Herrmann1Antje Schönfelder2Fabian Schwarzenberger3Holger Jentsch4Faculty, Department of Cariology, Endodontology and Periodontology, Centre for Periodontology, University Hospital of Leipzig, Leipzig, Germany.Student, Department of Cariology, Endodontology and Periodontology, Centre for Periodontology, University Hospital of Leipzig, Leipzig, Germany.Student, Department of Psychology, Clinical Research Organization, Leipzig, Germany.Professor, Faculty of Informatics/Mathematics, University of Applied Sciences, Dresden, Germany.Professor, Department of Cariology, Endodontology and Periodontology, Centre for Periodontology, University Hospital of Leipzig, Leipzig, Germany.Introduction: Over the years, numerous trials have sufficiently documented benefits of adjuvant administration of antibiotics in combination to Scaling and Root Planing (SRP) in treatment of periodontitis. Nevertheless there are justified doubts in respect to antibiotics administration with regard to increasing development of resistances. Aim: The aim of this review study and meta-analysis was to verify a possible benefit of Azithromycin (AZM) as an alternative adjuvant antibiotic in combination with SRP. Materials and Methods: Electronic databases (Pubmed) were searched from the earliest point of record until May 2015. A hand search was also conducted. The variables considered in this respect were Probing Depth (PD), Clinical Attachment Level (CAL), Bleeding on Probing (BOP) and SRP. A meta-analysis containing trials comparing SRP as a sole therapy with SRP and administration of AZM was produced once all of the data obtained had been reviewed. Results: Six randomised clinical trials were accepted into the review and the meta-analysis following the process of trial selection. Meta-analysis revealed larger overall effects by the systemic administration of AZM compared with SRP on their own in terms of PD, CAL, BOP, Plaque-Index and total bacterial load reduction after three and six months. Conclusion: The data used in this study revealed that the systemic administration of AZM is beneficial compared with SRP on its own for the treatment of chronic periodontitis.https://jcdr.net/articles/PDF/8115/20176_CE(EK)_F(AK)_PF1(EKAK)_PFA(AK)_PF2(PAG).pdfdrug therapyantibioticsperiodontal debridement |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Antonio Renatus Jörg Herrmann Antje Schönfelder Fabian Schwarzenberger Holger Jentsch |
spellingShingle |
Antonio Renatus Jörg Herrmann Antje Schönfelder Fabian Schwarzenberger Holger Jentsch Clinical Efficacy of Azithromycin as an Adjunctive Therapy to Non-Surgical Periodontal Treatment of Periodontitis: A Systematic Review and Meta-Analysis Journal of Clinical and Diagnostic Research drug therapy antibiotics periodontal debridement |
author_facet |
Antonio Renatus Jörg Herrmann Antje Schönfelder Fabian Schwarzenberger Holger Jentsch |
author_sort |
Antonio Renatus |
title |
Clinical Efficacy of Azithromycin as an Adjunctive Therapy to Non-Surgical Periodontal Treatment of Periodontitis: A Systematic Review and Meta-Analysis |
title_short |
Clinical Efficacy of Azithromycin as an Adjunctive Therapy to Non-Surgical Periodontal Treatment of Periodontitis: A Systematic Review and Meta-Analysis |
title_full |
Clinical Efficacy of Azithromycin as an Adjunctive Therapy to Non-Surgical Periodontal Treatment of Periodontitis: A Systematic Review and Meta-Analysis |
title_fullStr |
Clinical Efficacy of Azithromycin as an Adjunctive Therapy to Non-Surgical Periodontal Treatment of Periodontitis: A Systematic Review and Meta-Analysis |
title_full_unstemmed |
Clinical Efficacy of Azithromycin as an Adjunctive Therapy to Non-Surgical Periodontal Treatment of Periodontitis: A Systematic Review and Meta-Analysis |
title_sort |
clinical efficacy of azithromycin as an adjunctive therapy to non-surgical periodontal treatment of periodontitis: a systematic review and meta-analysis |
publisher |
JCDR Research and Publications Private Limited |
series |
Journal of Clinical and Diagnostic Research |
issn |
2249-782X 0973-709X |
publishDate |
2016-07-01 |
description |
Introduction: Over the years, numerous trials have sufficiently
documented benefits of adjuvant administration of antibiotics
in combination to Scaling and Root Planing (SRP) in treatment
of periodontitis. Nevertheless there are justified doubts in
respect to antibiotics administration with regard to increasing
development of resistances.
Aim: The aim of this review study and meta-analysis was to
verify a possible benefit of Azithromycin (AZM) as an alternative
adjuvant antibiotic in combination with SRP.
Materials and Methods: Electronic databases (Pubmed) were
searched from the earliest point of record until May 2015. A
hand search was also conducted. The variables considered in
this respect were Probing Depth (PD), Clinical Attachment Level
(CAL), Bleeding on Probing (BOP) and SRP. A meta-analysis
containing trials comparing SRP as a sole therapy with SRP
and administration of AZM was produced once all of the data
obtained had been reviewed.
Results: Six randomised clinical trials were accepted into the
review and the meta-analysis following the process of trial
selection. Meta-analysis revealed larger overall effects by the
systemic administration of AZM compared with SRP on their
own in terms of PD, CAL, BOP, Plaque-Index and total bacterial
load reduction after three and six months.
Conclusion: The data used in this study revealed that the
systemic administration of AZM is beneficial compared with
SRP on its own for the treatment of chronic periodontitis. |
topic |
drug therapy antibiotics periodontal debridement |
url |
https://jcdr.net/articles/PDF/8115/20176_CE(EK)_F(AK)_PF1(EKAK)_PFA(AK)_PF2(PAG).pdf |
work_keys_str_mv |
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