Perillyl alcohol as a treatment for cancer: A systematic review
Background: Cancer is the second leading cause of death in the world. Cancer treatment has many adverse effects, making the search for new therapeutic agents necessary. Objective: this systematic review aimed to assess the efficacy of perillyl alcohol (POH) in the treatment of cancer based on the ob...
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2021-08-01
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doaj-7f8f3bef26044c9bb4ae1fd2ca45af952021-08-14T04:32:10ZengElsevierPhytomedicine Plus2667-03132021-08-0113100090Perillyl alcohol as a treatment for cancer: A systematic reviewAimée Obolari Durço0Lino Sérgio Rocha Conceição1Diego Santos de Souza2Carlos Anselmo Lima3Jullyana de Souza Siqueira Quintans4Márcio Roberto Viana dos Santos5Health Sciences Graduate Program, Federal University of Sergipe, Hospital Universitário, S/N, rua Cláudio Batista, Sanatório 49060-108, Aracaju-Sergipe, BrazilDepartment of Physical Therapy, Federal University of Sergipe, Hospital Universitário, S/N, rua Cláudio Batista, Sanatório 49060-108, Aracaju-Sergipe, BrazilDepartment of Biophysics, Universidade Federal de São Paulo, rua Botucatu, 862, Vila Clementino 04023901, São Paulo-São Paulo, BrazilHealth Sciences Graduate Program, Federal University of Sergipe, Hospital Universitário, S/N, rua Cláudio Batista, Sanatório 49060-108, Aracaju-Sergipe, Brazil; Department of Medicine, Federal University of Sergipe, Av. Marechal Rondon, S/N, Rosa Elze 49.100-100, São Cristovão-Sergipe, BrazilHealth Sciences Graduate Program, Federal University of Sergipe, Hospital Universitário, S/N, rua Cláudio Batista, Sanatório 49060-108, Aracaju-Sergipe, Brazil; Department of Physiology, Federal University of Sergipe, Av. Marechal Rondon, S/N, Rosa Elze 49.100-100, São Cristovão-Sergipe, BrazilHealth Sciences Graduate Program, Federal University of Sergipe, Hospital Universitário, S/N, rua Cláudio Batista, Sanatório 49060-108, Aracaju-Sergipe, Brazil; Department of Physiology, Federal University of Sergipe, Av. Marechal Rondon, S/N, Rosa Elze 49.100-100, São Cristovão-Sergipe, Brazil; Corresponding author at: Department of Physiology, Federal University of Sergipe. Av. Marechal Rondon, S/N, Rosa Elze 49.100-100, São Cristovão-Sergipe, Brazil.Background: Cancer is the second leading cause of death in the world. Cancer treatment has many adverse effects, making the search for new therapeutic agents necessary. Objective: this systematic review aimed to assess the efficacy of perillyl alcohol (POH) in the treatment of cancer based on the objective response (OR). Methods: This review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Statement. The search was conducted in the PubMmed, Scopus, Web of Science, and Cochrane Library databases, and included clinical trials which reported in their results the anti-tumor activity of POH as an OR, and studies with isolated POH as treatment. The review excluded preclinical studies, in vitro trials, review articles, meta-analyses, abstracts, conference proceedings, editorials/letters, case reports, and studies assessing POH in other ways, not investigating it as an anticancer treatment. Data were extracted by two independent reviewers, using a table with pre-specified items. The risk of bias (RoB) in the included studies was assessed using the Cochrane risk of bias assessment tool. Results: Thirteen studies were identified, 7 phase I and 6 phase II trials. Eleven studies administrated POH by oral route and 2 by inhalation. Ten studies reported adverse effects. Among the selected studies, the cancer types most studied were colorectal, ovarian, breast, and prostate cancers. None of the selected studies achieved clinical complete response (CR) after POH treatment, three achieved partial response (PR) and several reported stable disease (SD). Of the three which achieved PR, two used the inhalation route for POH. Conclusion: The best evidence available shows that POH has little or no significant effect on objective response in different cancer types. However, the administration of POH by inhalation showed promising objective responses and outcomes. Taken together, these findings suggest a promising potential cytostatic effect of POH.http://www.sciencedirect.com/science/article/pii/S2667031321000725Perillyl alcoholCancerChemotherapyNatural product |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Aimée Obolari Durço Lino Sérgio Rocha Conceição Diego Santos de Souza Carlos Anselmo Lima Jullyana de Souza Siqueira Quintans Márcio Roberto Viana dos Santos |
spellingShingle |
Aimée Obolari Durço Lino Sérgio Rocha Conceição Diego Santos de Souza Carlos Anselmo Lima Jullyana de Souza Siqueira Quintans Márcio Roberto Viana dos Santos Perillyl alcohol as a treatment for cancer: A systematic review Phytomedicine Plus Perillyl alcohol Cancer Chemotherapy Natural product |
author_facet |
Aimée Obolari Durço Lino Sérgio Rocha Conceição Diego Santos de Souza Carlos Anselmo Lima Jullyana de Souza Siqueira Quintans Márcio Roberto Viana dos Santos |
author_sort |
Aimée Obolari Durço |
title |
Perillyl alcohol as a treatment for cancer: A systematic review |
title_short |
Perillyl alcohol as a treatment for cancer: A systematic review |
title_full |
Perillyl alcohol as a treatment for cancer: A systematic review |
title_fullStr |
Perillyl alcohol as a treatment for cancer: A systematic review |
title_full_unstemmed |
Perillyl alcohol as a treatment for cancer: A systematic review |
title_sort |
perillyl alcohol as a treatment for cancer: a systematic review |
publisher |
Elsevier |
series |
Phytomedicine Plus |
issn |
2667-0313 |
publishDate |
2021-08-01 |
description |
Background: Cancer is the second leading cause of death in the world. Cancer treatment has many adverse effects, making the search for new therapeutic agents necessary. Objective: this systematic review aimed to assess the efficacy of perillyl alcohol (POH) in the treatment of cancer based on the objective response (OR). Methods: This review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Statement. The search was conducted in the PubMmed, Scopus, Web of Science, and Cochrane Library databases, and included clinical trials which reported in their results the anti-tumor activity of POH as an OR, and studies with isolated POH as treatment. The review excluded preclinical studies, in vitro trials, review articles, meta-analyses, abstracts, conference proceedings, editorials/letters, case reports, and studies assessing POH in other ways, not investigating it as an anticancer treatment. Data were extracted by two independent reviewers, using a table with pre-specified items. The risk of bias (RoB) in the included studies was assessed using the Cochrane risk of bias assessment tool. Results: Thirteen studies were identified, 7 phase I and 6 phase II trials. Eleven studies administrated POH by oral route and 2 by inhalation. Ten studies reported adverse effects. Among the selected studies, the cancer types most studied were colorectal, ovarian, breast, and prostate cancers. None of the selected studies achieved clinical complete response (CR) after POH treatment, three achieved partial response (PR) and several reported stable disease (SD). Of the three which achieved PR, two used the inhalation route for POH. Conclusion: The best evidence available shows that POH has little or no significant effect on objective response in different cancer types. However, the administration of POH by inhalation showed promising objective responses and outcomes. Taken together, these findings suggest a promising potential cytostatic effect of POH. |
topic |
Perillyl alcohol Cancer Chemotherapy Natural product |
url |
http://www.sciencedirect.com/science/article/pii/S2667031321000725 |
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