Quantitative evaluation and comparison of coronary artery characteristics by 3D coronary volume reconstruction
Abstract Non-atherosclerotic abnormalities of vessel calibre, aneurysm and ectasia, are challenging to quantify and are often overlooked in qualitative reporting. Utilising a novel 3-dimensional (3D) quantitative coronary angiography (QCA) application, we have evaluated the characteristics of normal...
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2021-01-01
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Online Access: | https://doi.org/10.1038/s41598-020-80928-4 |
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doaj-7f9d326eab3243008722e1ba76538cc82021-01-17T12:39:35ZengNature Publishing GroupScientific Reports2045-23222021-01-011111810.1038/s41598-020-80928-4Quantitative evaluation and comparison of coronary artery characteristics by 3D coronary volume reconstructionYongcheol Kim0Jonathan James Hyett Bray1Benjamin Waterhouse2Alexander Gall3Georgia May Connolly4Eva Sammut5Vito Domenico Bruno6Robert Tulloh7David Adlam8Thomas W. Johnson9Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine and Cardiovascular Center, Yongin Severance HospitalUniversity of BristolBristol Heart Institute, University Hospitals Bristol NHS Foundation TrustBristol Heart Institute, University Hospitals Bristol NHS Foundation TrustBristol Heart Institute, University Hospitals Bristol NHS Foundation TrustBristol Heart Institute, University Hospitals Bristol NHS Foundation TrustUniversity of Bristol Medical School – Translational Health ScienceBristol Heart Institute, University Hospitals Bristol NHS Foundation TrustDepartment of Cardiovascular Sciences, NIHR Leicester Biomedical Research CentreBristol Heart Institute, University Hospitals Bristol NHS Foundation TrustAbstract Non-atherosclerotic abnormalities of vessel calibre, aneurysm and ectasia, are challenging to quantify and are often overlooked in qualitative reporting. Utilising a novel 3-dimensional (3D) quantitative coronary angiography (QCA) application, we have evaluated the characteristics of normal, diabetic and aneurysmal or ectatic coronary arteries. We selected 131 individuals under 50 years-of-age, who had undergone coronary angiography for suspected myocardial ischaemia between 1st January 2011 and 31st December 2015, at the Bristol Heart Institute, Bristol, UK. This included 42 patients with angiographically normal coronary arteries, 36 diabetic patients with unobstructed coronaries, and 53 patients with abnormal coronary dilatation (aneurysm and ectasia). A total of 1105 coronary segments were analysed using QAngio XA 3D (Research Edition, Medis medical imaging systems, Leiden, The Netherlands). The combined volume of the major coronary arteries was significantly different between each group (1240 ± 476 mm3 diabetic group, 1646 ± 391 mm3 normal group, and 2072 ± 687 mm3 abnormal group). Moreover, the combined coronary artery volumes correlated with patient body surface area (r = 0.483, p < 0.01). Inter-observer variability was assessed and intraclass correlation coefficient of the total coronary artery volume demonstrated a low variability of 3D QCA (r = 0.996, p < 0.001). Dedicated 3D QCA facilitates reproducible coronary artery volume estimation and allows discrimination of normal and diseased vessels.https://doi.org/10.1038/s41598-020-80928-4 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yongcheol Kim Jonathan James Hyett Bray Benjamin Waterhouse Alexander Gall Georgia May Connolly Eva Sammut Vito Domenico Bruno Robert Tulloh David Adlam Thomas W. Johnson |
spellingShingle |
Yongcheol Kim Jonathan James Hyett Bray Benjamin Waterhouse Alexander Gall Georgia May Connolly Eva Sammut Vito Domenico Bruno Robert Tulloh David Adlam Thomas W. Johnson Quantitative evaluation and comparison of coronary artery characteristics by 3D coronary volume reconstruction Scientific Reports |
author_facet |
Yongcheol Kim Jonathan James Hyett Bray Benjamin Waterhouse Alexander Gall Georgia May Connolly Eva Sammut Vito Domenico Bruno Robert Tulloh David Adlam Thomas W. Johnson |
author_sort |
Yongcheol Kim |
title |
Quantitative evaluation and comparison of coronary artery characteristics by 3D coronary volume reconstruction |
title_short |
Quantitative evaluation and comparison of coronary artery characteristics by 3D coronary volume reconstruction |
title_full |
Quantitative evaluation and comparison of coronary artery characteristics by 3D coronary volume reconstruction |
title_fullStr |
Quantitative evaluation and comparison of coronary artery characteristics by 3D coronary volume reconstruction |
title_full_unstemmed |
Quantitative evaluation and comparison of coronary artery characteristics by 3D coronary volume reconstruction |
title_sort |
quantitative evaluation and comparison of coronary artery characteristics by 3d coronary volume reconstruction |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2021-01-01 |
description |
Abstract Non-atherosclerotic abnormalities of vessel calibre, aneurysm and ectasia, are challenging to quantify and are often overlooked in qualitative reporting. Utilising a novel 3-dimensional (3D) quantitative coronary angiography (QCA) application, we have evaluated the characteristics of normal, diabetic and aneurysmal or ectatic coronary arteries. We selected 131 individuals under 50 years-of-age, who had undergone coronary angiography for suspected myocardial ischaemia between 1st January 2011 and 31st December 2015, at the Bristol Heart Institute, Bristol, UK. This included 42 patients with angiographically normal coronary arteries, 36 diabetic patients with unobstructed coronaries, and 53 patients with abnormal coronary dilatation (aneurysm and ectasia). A total of 1105 coronary segments were analysed using QAngio XA 3D (Research Edition, Medis medical imaging systems, Leiden, The Netherlands). The combined volume of the major coronary arteries was significantly different between each group (1240 ± 476 mm3 diabetic group, 1646 ± 391 mm3 normal group, and 2072 ± 687 mm3 abnormal group). Moreover, the combined coronary artery volumes correlated with patient body surface area (r = 0.483, p < 0.01). Inter-observer variability was assessed and intraclass correlation coefficient of the total coronary artery volume demonstrated a low variability of 3D QCA (r = 0.996, p < 0.001). Dedicated 3D QCA facilitates reproducible coronary artery volume estimation and allows discrimination of normal and diseased vessels. |
url |
https://doi.org/10.1038/s41598-020-80928-4 |
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