Diagnostic Value of Imaging Methods in the Histological Four Grading of Hepatocellular Carcinoma
We attempted to establish an ultrasound (US) imaging-diagnostic system for histopathological grades of differentiation of hepatocellular carcinoma (HCC). We conducted a retrospective study of histopathologically confirmed 200 HCCs, classified as early (45 lesions), well- (31 lesions), moderately (68...
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doaj-7f9feb78e5ed44ad938143481a7499712020-11-25T02:58:09ZengMDPI AGDiagnostics2075-44182020-05-011032132110.3390/diagnostics10050321Diagnostic Value of Imaging Methods in the Histological Four Grading of Hepatocellular CarcinomaFeiqian Wang0Kazushi Numata1Masayuki Nakano2Mikiko Tanabe3Makoto Chuma4Hiromi Nihonmatsu5Akito Nozaki6Katsuaki Ogushi7Wen Luo8Litao Ruan9Masahiro Okada10Masako Otani11Yoshiaki Inayama12Shin Maeda13Gastroenterological Center, Yokohama City University Medical Center, Yokohama 232-0024, JapanGastroenterological Center, Yokohama City University Medical Center, Yokohama 232-0024, JapanTokyo Central Pathology Laboratory, Hachioji 192-0024, JapanDivision of Diagnostic Pathology, Yokohama City University Medical Center, Kanagawa 232-0024, JapanGastroenterological Center, Yokohama City University Medical Center, Yokohama 232-0024, JapanGastroenterological Center, Yokohama City University Medical Center, Yokohama 232-0024, JapanGastroenterological Center, Yokohama City University Medical Center, Yokohama 232-0024, JapanGastroenterological Center, Yokohama City University Medical Center, Yokohama 232-0024, JapanDepartment of Ultrasound, Xijing Hospital, Air Force Military Medical University, Xi’an 710032, ChinaUltrasound Department, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, ChinaDepartment of Radiology, Nihon University School of Medicine, Tokyo 173-8610, JapanDivision of Diagnostic Pathology, Yokohama City University Medical Center, Kanagawa 232-0024, JapanDivision of Diagnostic Pathology, Yokohama City University Medical Center, Kanagawa 232-0024, JapanDivision of Gastroenterology, Yokohama City University Graduate School of Medicine, Kanagawa 236-0004, JapanWe attempted to establish an ultrasound (US) imaging-diagnostic system for histopathological grades of differentiation of hepatocellular carcinoma (HCC). We conducted a retrospective study of histopathologically confirmed 200 HCCs, classified as early (45 lesions), well- (31 lesions), moderately (68 lesions) or poorly differentiated (diff.) (56 lesions) HCCs. We performed grayscale US to estimate the presence/absence of halo and mosaic signs, Sonazoid contrast-enhanced US (CEUS) to determine vascularity (hypo/iso/hyper) of lesion in arterial and portal phase (PP), and echogenicity of lesion in post-vascular phase (PVP). All findings were of significance for the diagnosis of some (but not all) histological grades <i>(p</i> < 0.001–0.05). Combined findings with a relatively high diagnostic efficacy for early, poorly and moderately diff. HCC were a combination of absence of halo sign and isoechogenicity in PVP of CEUS (accuracy: 93.0%, AUC: 0.908), hypovascularity in PP (accuracy: 78.0%, area under the curve (AUC): 0.750), and a combination of isovascularity in PP and hypoechogenicity in PVP (accuracy: 75.0%, AUC: 0.739), respectively. On the other hand, neither any individual finding nor any combination of findings yielded an AUC of over 0.657 for the diagnosis of well-diff. HCC. Our study provides encouraging data on Sonazoid CEUS in the histological differential diagnosis of HCC, especially in early HCC, and the effectiveness of this imaging method should be further proved by prospective, large sample, multicenter studies.https://www.mdpi.com/2075-4418/10/5/321hepatocellular carcinomacontrast-enhanced ultrasoundhistological gradediagnosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Feiqian Wang Kazushi Numata Masayuki Nakano Mikiko Tanabe Makoto Chuma Hiromi Nihonmatsu Akito Nozaki Katsuaki Ogushi Wen Luo Litao Ruan Masahiro Okada Masako Otani Yoshiaki Inayama Shin Maeda |
spellingShingle |
Feiqian Wang Kazushi Numata Masayuki Nakano Mikiko Tanabe Makoto Chuma Hiromi Nihonmatsu Akito Nozaki Katsuaki Ogushi Wen Luo Litao Ruan Masahiro Okada Masako Otani Yoshiaki Inayama Shin Maeda Diagnostic Value of Imaging Methods in the Histological Four Grading of Hepatocellular Carcinoma Diagnostics hepatocellular carcinoma contrast-enhanced ultrasound histological grade diagnosis |
author_facet |
Feiqian Wang Kazushi Numata Masayuki Nakano Mikiko Tanabe Makoto Chuma Hiromi Nihonmatsu Akito Nozaki Katsuaki Ogushi Wen Luo Litao Ruan Masahiro Okada Masako Otani Yoshiaki Inayama Shin Maeda |
author_sort |
Feiqian Wang |
title |
Diagnostic Value of Imaging Methods in the Histological Four Grading of Hepatocellular Carcinoma |
title_short |
Diagnostic Value of Imaging Methods in the Histological Four Grading of Hepatocellular Carcinoma |
title_full |
Diagnostic Value of Imaging Methods in the Histological Four Grading of Hepatocellular Carcinoma |
title_fullStr |
Diagnostic Value of Imaging Methods in the Histological Four Grading of Hepatocellular Carcinoma |
title_full_unstemmed |
Diagnostic Value of Imaging Methods in the Histological Four Grading of Hepatocellular Carcinoma |
title_sort |
diagnostic value of imaging methods in the histological four grading of hepatocellular carcinoma |
publisher |
MDPI AG |
series |
Diagnostics |
issn |
2075-4418 |
publishDate |
2020-05-01 |
description |
We attempted to establish an ultrasound (US) imaging-diagnostic system for histopathological grades of differentiation of hepatocellular carcinoma (HCC). We conducted a retrospective study of histopathologically confirmed 200 HCCs, classified as early (45 lesions), well- (31 lesions), moderately (68 lesions) or poorly differentiated (diff.) (56 lesions) HCCs. We performed grayscale US to estimate the presence/absence of halo and mosaic signs, Sonazoid contrast-enhanced US (CEUS) to determine vascularity (hypo/iso/hyper) of lesion in arterial and portal phase (PP), and echogenicity of lesion in post-vascular phase (PVP). All findings were of significance for the diagnosis of some (but not all) histological grades <i>(p</i> < 0.001–0.05). Combined findings with a relatively high diagnostic efficacy for early, poorly and moderately diff. HCC were a combination of absence of halo sign and isoechogenicity in PVP of CEUS (accuracy: 93.0%, AUC: 0.908), hypovascularity in PP (accuracy: 78.0%, area under the curve (AUC): 0.750), and a combination of isovascularity in PP and hypoechogenicity in PVP (accuracy: 75.0%, AUC: 0.739), respectively. On the other hand, neither any individual finding nor any combination of findings yielded an AUC of over 0.657 for the diagnosis of well-diff. HCC. Our study provides encouraging data on Sonazoid CEUS in the histological differential diagnosis of HCC, especially in early HCC, and the effectiveness of this imaging method should be further proved by prospective, large sample, multicenter studies. |
topic |
hepatocellular carcinoma contrast-enhanced ultrasound histological grade diagnosis |
url |
https://www.mdpi.com/2075-4418/10/5/321 |
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