The Unfolded Protein Response Pathway in the Yeast Kluyveromyces lactis. A Comparative View among Yeast Species
Eukaryotic cells have evolved signalling pathways that allow adaptation to harmful conditions that disrupt endoplasmic reticulum (ER) homeostasis. When the function of the ER is compromised in a condition known as ER stress, the cell triggers the unfolded protein response (UPR) in order to restore E...
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doaj-7fa4ce6de3a4413faddcbff5a07459772020-11-25T02:26:32ZengMDPI AGCells2073-44092018-08-017810610.3390/cells7080106cells7080106The Unfolded Protein Response Pathway in the Yeast Kluyveromyces lactis. A Comparative View among Yeast SpeciesMariana Hernández-Elvira0Francisco Torres-Quiroz1Abril Escamilla-Ayala2Eunice Domínguez-Martin3Ricardo Escalante4Laura Kawasaki5Laura Ongay-Larios6Roberto Coria7Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, 04510 Mexico City, MexicoDepartamento de Bioquímica y Biología Estructural, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, 04510 Mexico City, MexicoLaboratory for Membrane Trafficking, VIB-KU Leuven Center for Brain & Disease Research and Department of Neurosciences, KU Leuven, 3000 Leuven, BelgiumDepartamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, 04510 Mexico City, MexicoInstituto de Investigaciones Biomédicas “Alberto Sols” (CSIC-UAM), Arturo Duperier 4, 28029 Madrid, SpainDepartamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, 04510 Mexico City, MexicoUnidad de Biología Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, 04510 Mexico City, MexicoDepartamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, 04510 Mexico City, MexicoEukaryotic cells have evolved signalling pathways that allow adaptation to harmful conditions that disrupt endoplasmic reticulum (ER) homeostasis. When the function of the ER is compromised in a condition known as ER stress, the cell triggers the unfolded protein response (UPR) in order to restore ER homeostasis. Accumulation of misfolded proteins due to stress conditions activates the UPR pathway. In mammalian cells, the UPR is composed of three branches, each containing an ER sensor (PERK, ATF6 and IRE1). However, in yeast species, the only sensor present is the inositol-requiring enzyme Ire1. To cope with unfolded protein accumulation, Ire1 triggers either a transcriptional response mediated by a transcriptional factor that belongs to the bZIP transcription factor family or an mRNA degradation process. In this review, we address the current knowledge of the UPR pathway in several yeast species: Saccharomyces cerevisiae, Schizosaccharomyces pombe, Candida glabrata, Cryptococcus neoformans, and Candida albicans. We also include unpublished data on the UPR pathway of the budding yeast Kluyveromyces lactis. We describe the basic components of the UPR pathway along with similarities and differences in the UPR mechanism that are present in these yeast species.http://www.mdpi.com/2073-4409/7/8/106yeastendoplasmic reticulumstressUPRIre1Hac1Kar2 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mariana Hernández-Elvira Francisco Torres-Quiroz Abril Escamilla-Ayala Eunice Domínguez-Martin Ricardo Escalante Laura Kawasaki Laura Ongay-Larios Roberto Coria |
spellingShingle |
Mariana Hernández-Elvira Francisco Torres-Quiroz Abril Escamilla-Ayala Eunice Domínguez-Martin Ricardo Escalante Laura Kawasaki Laura Ongay-Larios Roberto Coria The Unfolded Protein Response Pathway in the Yeast Kluyveromyces lactis. A Comparative View among Yeast Species Cells yeast endoplasmic reticulum stress UPR Ire1 Hac1 Kar2 |
author_facet |
Mariana Hernández-Elvira Francisco Torres-Quiroz Abril Escamilla-Ayala Eunice Domínguez-Martin Ricardo Escalante Laura Kawasaki Laura Ongay-Larios Roberto Coria |
author_sort |
Mariana Hernández-Elvira |
title |
The Unfolded Protein Response Pathway in the Yeast Kluyveromyces lactis. A Comparative View among Yeast Species |
title_short |
The Unfolded Protein Response Pathway in the Yeast Kluyveromyces lactis. A Comparative View among Yeast Species |
title_full |
The Unfolded Protein Response Pathway in the Yeast Kluyveromyces lactis. A Comparative View among Yeast Species |
title_fullStr |
The Unfolded Protein Response Pathway in the Yeast Kluyveromyces lactis. A Comparative View among Yeast Species |
title_full_unstemmed |
The Unfolded Protein Response Pathway in the Yeast Kluyveromyces lactis. A Comparative View among Yeast Species |
title_sort |
unfolded protein response pathway in the yeast kluyveromyces lactis. a comparative view among yeast species |
publisher |
MDPI AG |
series |
Cells |
issn |
2073-4409 |
publishDate |
2018-08-01 |
description |
Eukaryotic cells have evolved signalling pathways that allow adaptation to harmful conditions that disrupt endoplasmic reticulum (ER) homeostasis. When the function of the ER is compromised in a condition known as ER stress, the cell triggers the unfolded protein response (UPR) in order to restore ER homeostasis. Accumulation of misfolded proteins due to stress conditions activates the UPR pathway. In mammalian cells, the UPR is composed of three branches, each containing an ER sensor (PERK, ATF6 and IRE1). However, in yeast species, the only sensor present is the inositol-requiring enzyme Ire1. To cope with unfolded protein accumulation, Ire1 triggers either a transcriptional response mediated by a transcriptional factor that belongs to the bZIP transcription factor family or an mRNA degradation process. In this review, we address the current knowledge of the UPR pathway in several yeast species: Saccharomyces cerevisiae, Schizosaccharomyces pombe, Candida glabrata, Cryptococcus neoformans, and Candida albicans. We also include unpublished data on the UPR pathway of the budding yeast Kluyveromyces lactis. We describe the basic components of the UPR pathway along with similarities and differences in the UPR mechanism that are present in these yeast species. |
topic |
yeast endoplasmic reticulum stress UPR Ire1 Hac1 Kar2 |
url |
http://www.mdpi.com/2073-4409/7/8/106 |
work_keys_str_mv |
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