Inflammaging and Frailty Status Do Not Result in an Increased Extracellular Vesicle Concentration in Circulation

• Main Authors: Ainhoa Alberro, Matías Sáenz-Cuesta, Maider Muñoz-Culla, Maider Mateo-Abad, Esperanza Gonzalez, Estefania Carrasco-Garcia, Marcos J. Araúzo-Bravo, Ander Matheu, Itziar Vergara, David Otaegui
• Format: Article
• Language: English
• Published: MDPI AG 2016-07-01
• Series: International Journal of Molecular Sciences
• Subjects: extracellular vesicle; intercellular communication; human aging; inflammaging; frailty; interleukin-6
• Online Access: http://www.mdpi.com/1422-0067/17/7/1168

In the last decades extracellular vesicles (EVs) have emerged as key players for intercellular communication. In the case of inflammation, several studies have reported that EV levels are increased in circulation during inflammatory episodes. Based on this, we investigated whether aging results in elevated EV number, as a basal proinflammatory status termed “inflammaging” has been described in aged individuals. Moreover, we also hypothesized that frailty and dependence conditions of the elderly could affect EV concentration in plasma. Results showed that inflammaging, frailty or dependence status do not result in EV increase, at least in the total number of EVs in circulation. These results open a new perspective for investigating the role of EVs in human aging and in the inflammaging process.