Hemodynamic Effects of Alpha-Tropomyosin Mutations Associated with Inherited Cardiomyopathies: Multiscale Simulation

Hemodynamic Effects of Alpha-Tropomyosin Mutations Associated with Inherited Cardiomyopathies: Multiscale Simulation

The effects of two cardiomyopathy-associated mutations in regulatory sarcomere protein tropomyosin (Tpm) on heart function were studied with a new multiscale model of the cardiovascular system (CVS). They were a Tpm mutation, Ile284Val, associated with hypertrophic cardiomyopathy (HCM), and an Asp23...

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Bibliographic Details
Main Authors:	Fyodor Syomin, Albina Khabibullina, Anna Osepyan, Andrey Tsaturyan
Format:	Article
Language:	English
Published:	MDPI AG 2020-07-01
Series:	Mathematics
Subjects:	mathematical modeling cardiac mechanics multiscale simulation cardiomyopathies left ventricle remodeling
Online Access:	https://www.mdpi.com/2227-7390/8/7/1169

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