Calprotectin and cross-linked N-telopeptides of type I collagen levels in crevicular fluid from implant sites with peri-implant diseases: a pilot study
Abstract Background Peri-implant crevicular fluid (PICF) contains calprotectin and NTx, which are markers for inflammation and bone resorption, respectively. The aims of this pilot study were to compare calprotectin and NTx levels in PICF from implant sites with or without peri-implant diseases and...
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doaj-7fc964a2347c443ca1d29e14ec9a52222020-11-24T21:58:39ZengSpringerOpenInternational Journal of Implant Dentistry2198-40342018-09-01411810.1186/s40729-018-0138-2Calprotectin and cross-linked N-telopeptides of type I collagen levels in crevicular fluid from implant sites with peri-implant diseases: a pilot studyEijiro Sakamoto0Rie Kido1Yoritoki Tomotake2Yoshihito Naitou3Yuichi Ishida4Jun-ichi Kido5Department of Periodontology and Endodontology, Institute of Biomedical Sciences, Tokushima University Graduate SchoolDepartment of Periodontology and Endodontology, Institute of Biomedical Sciences, Tokushima University Graduate SchoolOral Implant Center, Tokushima University HospitalOral Implant Center, Tokushima University HospitalDepartment of Oral and Maxillofacial Prosthodontics, Institute of Biomedical Sciences, Tokushima University Graduate SchoolDepartment of Periodontology and Endodontology, Institute of Biomedical Sciences, Tokushima University Graduate SchoolAbstract Background Peri-implant crevicular fluid (PICF) contains calprotectin and NTx, which are markers for inflammation and bone resorption, respectively. The aims of this pilot study were to compare calprotectin and NTx levels in PICF from implant sites with or without peri-implant diseases and to evaluate the usefulness of calprotectin and NTx as diagnostic markers for peri-implant diseases. Methods Thirty-five patients with dental implants participated in this pilot study. PICF samples were collected from peri-implant disease sites (n = 40) and non-diseased (healthy) sites (n = 34) after clinical indicators including probing depth (PD), bleeding on probing (BOP), gingival index (GI), and bone loss (BL) rate were investigated. Calprotectin and NTx amounts in PICF were measured using their respective ELISA kits and then compared between diseased and healthy samples. The relationship between PICF calprotectin or NTx levels and clinical indicator levels was investigated. A receiver operating characteristic (ROC) curve analysis of calprotectin and NTx was performed to predict peri-implant diseases. Results Calprotectin and NTx levels in PICF were significantly higher from peri-implant disease sites than from healthy sites. PICF calprotectin amounts correlated with PD, and its levels were significantly higher in the GI-1 and GI-2 groups than in the GI-0 group. PICF NTx amounts correlated with PD and the BL rate. ROC curves indicated that PICF calprotectin and NTx are useful biomarkers for peri-implant diseases. Conclusions Calprotectin and NTx in PICF have potential as biomarkers for the diagnosis of peri-implant diseases.http://link.springer.com/article/10.1186/s40729-018-0138-2CalprotectinNTxPeri-implant crevicular fluidPeri-implant diseases |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Eijiro Sakamoto Rie Kido Yoritoki Tomotake Yoshihito Naitou Yuichi Ishida Jun-ichi Kido |
spellingShingle |
Eijiro Sakamoto Rie Kido Yoritoki Tomotake Yoshihito Naitou Yuichi Ishida Jun-ichi Kido Calprotectin and cross-linked N-telopeptides of type I collagen levels in crevicular fluid from implant sites with peri-implant diseases: a pilot study International Journal of Implant Dentistry Calprotectin NTx Peri-implant crevicular fluid Peri-implant diseases |
author_facet |
Eijiro Sakamoto Rie Kido Yoritoki Tomotake Yoshihito Naitou Yuichi Ishida Jun-ichi Kido |
author_sort |
Eijiro Sakamoto |
title |
Calprotectin and cross-linked N-telopeptides of type I collagen levels in crevicular fluid from implant sites with peri-implant diseases: a pilot study |
title_short |
Calprotectin and cross-linked N-telopeptides of type I collagen levels in crevicular fluid from implant sites with peri-implant diseases: a pilot study |
title_full |
Calprotectin and cross-linked N-telopeptides of type I collagen levels in crevicular fluid from implant sites with peri-implant diseases: a pilot study |
title_fullStr |
Calprotectin and cross-linked N-telopeptides of type I collagen levels in crevicular fluid from implant sites with peri-implant diseases: a pilot study |
title_full_unstemmed |
Calprotectin and cross-linked N-telopeptides of type I collagen levels in crevicular fluid from implant sites with peri-implant diseases: a pilot study |
title_sort |
calprotectin and cross-linked n-telopeptides of type i collagen levels in crevicular fluid from implant sites with peri-implant diseases: a pilot study |
publisher |
SpringerOpen |
series |
International Journal of Implant Dentistry |
issn |
2198-4034 |
publishDate |
2018-09-01 |
description |
Abstract Background Peri-implant crevicular fluid (PICF) contains calprotectin and NTx, which are markers for inflammation and bone resorption, respectively. The aims of this pilot study were to compare calprotectin and NTx levels in PICF from implant sites with or without peri-implant diseases and to evaluate the usefulness of calprotectin and NTx as diagnostic markers for peri-implant diseases. Methods Thirty-five patients with dental implants participated in this pilot study. PICF samples were collected from peri-implant disease sites (n = 40) and non-diseased (healthy) sites (n = 34) after clinical indicators including probing depth (PD), bleeding on probing (BOP), gingival index (GI), and bone loss (BL) rate were investigated. Calprotectin and NTx amounts in PICF were measured using their respective ELISA kits and then compared between diseased and healthy samples. The relationship between PICF calprotectin or NTx levels and clinical indicator levels was investigated. A receiver operating characteristic (ROC) curve analysis of calprotectin and NTx was performed to predict peri-implant diseases. Results Calprotectin and NTx levels in PICF were significantly higher from peri-implant disease sites than from healthy sites. PICF calprotectin amounts correlated with PD, and its levels were significantly higher in the GI-1 and GI-2 groups than in the GI-0 group. PICF NTx amounts correlated with PD and the BL rate. ROC curves indicated that PICF calprotectin and NTx are useful biomarkers for peri-implant diseases. Conclusions Calprotectin and NTx in PICF have potential as biomarkers for the diagnosis of peri-implant diseases. |
topic |
Calprotectin NTx Peri-implant crevicular fluid Peri-implant diseases |
url |
http://link.springer.com/article/10.1186/s40729-018-0138-2 |
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