Functional MRI activation in white matter during the Symbol Digit Modalities Test
Background: Recent evidence shows that functional magnetic resonance imaging (fMRI) can detect activation in white matter (WM). Such advances have important implications for understanding WM dysfunction. A key step in linking neuroimaging advances to the evaluation of clinical disorders is to examin...
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2014-08-01
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doaj-7fce63edd4b247959ad727267b5b2d112020-11-25T02:37:39ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612014-08-01810.3389/fnhum.2014.0058996302Functional MRI activation in white matter during the Symbol Digit Modalities TestJodie Reanna Gawryluk0Erin Lindsay Mazerolle1Steven eBeyea2Ryan eD'Arcy3University of VictoriaUniversity of CalgaryDalhousie UniversitySimon Fraser UniversityBackground: Recent evidence shows that functional magnetic resonance imaging (fMRI) can detect activation in white matter (WM). Such advances have important implications for understanding WM dysfunction. A key step in linking neuroimaging advances to the evaluation of clinical disorders is to examine whether WM activation can be detected at the individual level during clinical tests associated with WM function. We used an adapted Symbol Digit Modalities Test (SDMT) in a 4T fMRI study of healthy adults.Results: Results from 17 healthy individuals revealed WM activation in 88% of participants (15/17). The activation was in either the corpus callosum (anterior and/or posterior) or internal capsule (left and/or right). Conclusions: The findings link advances in fMRI to an established clinical test of WM function. Future work should focus on evaluating patients with WM dysfunction.http://journal.frontiersin.org/Journal/10.3389/fnhum.2014.00589/fullNeuroimagingNeuropsychologyfunctional magnetic resonance imagingwhite matterSymbol Digit Modalities Test |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jodie Reanna Gawryluk Erin Lindsay Mazerolle Steven eBeyea Ryan eD'Arcy |
spellingShingle |
Jodie Reanna Gawryluk Erin Lindsay Mazerolle Steven eBeyea Ryan eD'Arcy Functional MRI activation in white matter during the Symbol Digit Modalities Test Frontiers in Human Neuroscience Neuroimaging Neuropsychology functional magnetic resonance imaging white matter Symbol Digit Modalities Test |
author_facet |
Jodie Reanna Gawryluk Erin Lindsay Mazerolle Steven eBeyea Ryan eD'Arcy |
author_sort |
Jodie Reanna Gawryluk |
title |
Functional MRI activation in white matter during the Symbol Digit Modalities Test |
title_short |
Functional MRI activation in white matter during the Symbol Digit Modalities Test |
title_full |
Functional MRI activation in white matter during the Symbol Digit Modalities Test |
title_fullStr |
Functional MRI activation in white matter during the Symbol Digit Modalities Test |
title_full_unstemmed |
Functional MRI activation in white matter during the Symbol Digit Modalities Test |
title_sort |
functional mri activation in white matter during the symbol digit modalities test |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Human Neuroscience |
issn |
1662-5161 |
publishDate |
2014-08-01 |
description |
Background: Recent evidence shows that functional magnetic resonance imaging (fMRI) can detect activation in white matter (WM). Such advances have important implications for understanding WM dysfunction. A key step in linking neuroimaging advances to the evaluation of clinical disorders is to examine whether WM activation can be detected at the individual level during clinical tests associated with WM function. We used an adapted Symbol Digit Modalities Test (SDMT) in a 4T fMRI study of healthy adults.Results: Results from 17 healthy individuals revealed WM activation in 88% of participants (15/17). The activation was in either the corpus callosum (anterior and/or posterior) or internal capsule (left and/or right). Conclusions: The findings link advances in fMRI to an established clinical test of WM function. Future work should focus on evaluating patients with WM dysfunction. |
topic |
Neuroimaging Neuropsychology functional magnetic resonance imaging white matter Symbol Digit Modalities Test |
url |
http://journal.frontiersin.org/Journal/10.3389/fnhum.2014.00589/full |
work_keys_str_mv |
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1724794130783010816 |