Gene Co-expression Analysis Identifies Histone Deacetylase 5 and 9 Expression in Midbrain Dopamine Neurons and as Regulators of Neurite Growth via Bone Morphogenetic Protein Signaling

Gene Co-expression Analysis Identifies Histone Deacetylase 5 and 9 Expression in Midbrain Dopamine Neurons and as Regulators of Neurite Growth via Bone Morphogenetic Protein Signaling

Parkinson’s disease is characterized by the intracellular accumulation of α-synuclein which has been linked to early dopaminergic axonal degeneration. Identifying druggable targets that can promote axonal growth in cells overexpressing α-synuclein is important in order to develop strategies for earl...

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Bibliographic Details
Main Authors: Martina Mazzocchi, Sean L. Wyatt, Daniela Mercatelli, Michele Morari, Noelia Morales-Prieto, Louise M. Collins, Aideen M. Sullivan, Gerard W. O’Keeffe
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Parkinson’s
alpha-synuclein
degeneration
histone deacetylase
neurite growth
survival
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2019.00191/full

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