Structural Changes on MRI Demonstrate Specific Cerebellar Involvement in SLE Patients—A VBM Study
The purpose of this study is to investigate possible differences in brain structure, as measured by T1-weighted MRI, between patients with systemic lupus erythematosus (SLE) and healthy controls (HC), and whether any observed differences were in turn more severe in SLE patients with neuropsychiatric...
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doaj-7fd3a85423c9416c898a8d98507eab2a2021-04-16T23:05:18ZengMDPI AGBrain Sciences2076-34252021-04-011151051010.3390/brainsci11040510Structural Changes on MRI Demonstrate Specific Cerebellar Involvement in SLE Patients—A VBM StudyJohan Mårtensson0Theodor Rumetshofer1Jessika Nystedt2Jimmy Lätt3Petra Nilsson4Anders Bengtsson5Andreas Jönsen6Pia C. Sundgren7Department of Clinical Sciences Lund, Logopedics, Phoniatrics and Audiology, Faculty of Medicine, Lund University, 221 00 Lund, SwedenDepartment of Clinical Sciences Lund, Diagnostic Radiology, Faculty of Medicine, Lund University, 221 00 Lund, SwedenDepartment of Clinical Sciences Lund, Diagnostic Radiology, Faculty of Medicine, Lund University, 221 00 Lund, SwedenDepartment of Clinical Sciences Lund, MR Physics, Faculty of Medicine, Lund University, 221 00 Lund, SwedenDepartment of Clinical Sciences Lund, Neurology, Faculty of Medicine, Lund University, 221 00 Lund, SwedenDepartment of Clinical Sciences Lund, Rheumatology, Faculty of Medicine, Lund University, 221 00 Lund, SwedenDepartment of Clinical Sciences Lund, Rheumatology, Faculty of Medicine, Lund University, 221 00 Lund, SwedenDepartment of Clinical Sciences Lund, Diagnostic Radiology, Faculty of Medicine, Lund University, 221 00 Lund, SwedenThe purpose of this study is to investigate possible differences in brain structure, as measured by T1-weighted MRI, between patients with systemic lupus erythematosus (SLE) and healthy controls (HC), and whether any observed differences were in turn more severe in SLE patients with neuropsychiatric manifestations (NPSLE) than those without (non-NPSLE). Structural T1-weighted MRI was performed on 69 female SLE patients (mean age = 35.8 years, range = 18–51 years) and 24 age-matched female HC (mean age = 36.8 years, range = 23–52 years) in conjunction with neuropsychological assessment using the CNS Vital Signs test battery. T1-weighted images were preprocessed and analyzed by FSL-VBM. The results show that SLE patients had lower grey matter probability values than the control group in the VIIIa of the cerebellum bilaterally, a region that has previously been implied in sensorimotor processing in human and non-human primates. No structural differences for this region were found between NPSLE and non-NPSLE patients. VBM values from the VIIIa region showed a weak positive correlation with the psychomotor speed domain from CNS Vital Signs (<i>p</i> = 0.05, <i>r</i> = 0.21), which is in line with its presumed role as a sensorimotor processing area.https://www.mdpi.com/2076-3425/11/4/510lupusneuroimagingVBMcerebellum |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Johan Mårtensson Theodor Rumetshofer Jessika Nystedt Jimmy Lätt Petra Nilsson Anders Bengtsson Andreas Jönsen Pia C. Sundgren |
spellingShingle |
Johan Mårtensson Theodor Rumetshofer Jessika Nystedt Jimmy Lätt Petra Nilsson Anders Bengtsson Andreas Jönsen Pia C. Sundgren Structural Changes on MRI Demonstrate Specific Cerebellar Involvement in SLE Patients—A VBM Study Brain Sciences lupus neuroimaging VBM cerebellum |
author_facet |
Johan Mårtensson Theodor Rumetshofer Jessika Nystedt Jimmy Lätt Petra Nilsson Anders Bengtsson Andreas Jönsen Pia C. Sundgren |
author_sort |
Johan Mårtensson |
title |
Structural Changes on MRI Demonstrate Specific Cerebellar Involvement in SLE Patients—A VBM Study |
title_short |
Structural Changes on MRI Demonstrate Specific Cerebellar Involvement in SLE Patients—A VBM Study |
title_full |
Structural Changes on MRI Demonstrate Specific Cerebellar Involvement in SLE Patients—A VBM Study |
title_fullStr |
Structural Changes on MRI Demonstrate Specific Cerebellar Involvement in SLE Patients—A VBM Study |
title_full_unstemmed |
Structural Changes on MRI Demonstrate Specific Cerebellar Involvement in SLE Patients—A VBM Study |
title_sort |
structural changes on mri demonstrate specific cerebellar involvement in sle patients—a vbm study |
publisher |
MDPI AG |
series |
Brain Sciences |
issn |
2076-3425 |
publishDate |
2021-04-01 |
description |
The purpose of this study is to investigate possible differences in brain structure, as measured by T1-weighted MRI, between patients with systemic lupus erythematosus (SLE) and healthy controls (HC), and whether any observed differences were in turn more severe in SLE patients with neuropsychiatric manifestations (NPSLE) than those without (non-NPSLE). Structural T1-weighted MRI was performed on 69 female SLE patients (mean age = 35.8 years, range = 18–51 years) and 24 age-matched female HC (mean age = 36.8 years, range = 23–52 years) in conjunction with neuropsychological assessment using the CNS Vital Signs test battery. T1-weighted images were preprocessed and analyzed by FSL-VBM. The results show that SLE patients had lower grey matter probability values than the control group in the VIIIa of the cerebellum bilaterally, a region that has previously been implied in sensorimotor processing in human and non-human primates. No structural differences for this region were found between NPSLE and non-NPSLE patients. VBM values from the VIIIa region showed a weak positive correlation with the psychomotor speed domain from CNS Vital Signs (<i>p</i> = 0.05, <i>r</i> = 0.21), which is in line with its presumed role as a sensorimotor processing area. |
topic |
lupus neuroimaging VBM cerebellum |
url |
https://www.mdpi.com/2076-3425/11/4/510 |
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