AGO-accessible anticancer siRNAs designed with synergistic miRNA-like activity

AGO-accessible anticancer siRNAs designed with synergistic miRNA-like activity

Small interfering RNAs (siRNAs) therapeutically induce RNA interference (RNAi) of disease-causing genes, but they also silence hundreds of seed-matched off-targets as behaving similar to microRNAs (miRNAs). miRNAs control the pathophysiology of tumors, wherein their accessible binding sites can be s...

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Bibliographic Details
Main Authors: Dowoon Gu, Seung Hyun Ahn, Sangkyeong Eom, Hye-Sook Lee, Juyoung Ham, Dong Ha Lee, You Kyung Cho, Yongjun Koh, Elizaveta Ignatova, Eun-Sook Jang, Sung Wook Chi
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
siRNA
miRNA
AGO CLIP
cervical cancer
ovarian cancer
breast cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253121000184

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