Copper and zinc isotopic excursions in the human brain affected by Alzheimer's disease
Abstract Introduction Alzheimer's disease (AD) is neuropathologically marked by amyloid beta (Aβ) plaques and neurofibrillary tangles. Little is known about isotopic compositions of human AD brains. Here we study this in comparison with control subjects for copper and zinc. Methods We use mass‐...
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doaj-7fe73e95020b439483a23c4430de746f2021-04-15T14:35:47ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292020-01-01121n/an/a10.1002/dad2.12112Copper and zinc isotopic excursions in the human brain affected by Alzheimer's diseaseFrédéric Moynier0Marie Le Borgne1Esther Lahoud2Brandon Mahan3Francois Mouton‐Ligier4Jacques Hugon5Claire Paquet6Institut de Physique du Globe de Paris Université de Paris CNRS Paris FranceUnité 1148, Institut National de la Santé et de la Recherche Médicale (INSERM) Hôpital Xavier Bichat GHU Nord APHP Département Hospitalo‐Universitaire DHU FIRE Université de Paris Paris FranceInstitut de Physique du Globe de Paris Université de Paris CNRS Paris FranceEarth and Environmental Sciences James Cook University Townsville Queensland AustraliaCentre de Neurologie Cognitive Hopital Lariboisière Fernand‐Widal GHU Nord APHP Université de Paris, and Inserm Paris FranceCentre de Neurologie Cognitive Hopital Lariboisière Fernand‐Widal GHU Nord APHP Université de Paris, and Inserm Paris FranceCentre de Neurologie Cognitive Hopital Lariboisière Fernand‐Widal GHU Nord APHP Université de Paris, and Inserm Paris FranceAbstract Introduction Alzheimer's disease (AD) is neuropathologically marked by amyloid beta (Aβ) plaques and neurofibrillary tangles. Little is known about isotopic compositions of human AD brains. Here we study this in comparison with control subjects for copper and zinc. Methods We use mass‐spectrometry methods, developed to study extraterrestrial materials, to compare the copper and zinc isotopic composition of 10 AD and 10 control brains. Results Copper and zinc natural isotopic compositions of AD brains are statistically different compared to controls, and correlate with Braak stages. Discussion The distribution of natural copper and zinc isotopes in AD is not affected by the diet, but is a consequence of Aβ plaques and tau fibril accumulation. This is well predicted by the changes of the chemical bonding environment caused by the development of Aβ lesions and accumulation of tau proteins. Future work will involve testing whether these changes affect brain functions and are propagated to body fluids.https://doi.org/10.1002/dad2.12112Alzheimer's diseaseamyloid betacopperisotopes |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Frédéric Moynier Marie Le Borgne Esther Lahoud Brandon Mahan Francois Mouton‐Ligier Jacques Hugon Claire Paquet |
spellingShingle |
Frédéric Moynier Marie Le Borgne Esther Lahoud Brandon Mahan Francois Mouton‐Ligier Jacques Hugon Claire Paquet Copper and zinc isotopic excursions in the human brain affected by Alzheimer's disease Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring Alzheimer's disease amyloid beta copper isotopes |
author_facet |
Frédéric Moynier Marie Le Borgne Esther Lahoud Brandon Mahan Francois Mouton‐Ligier Jacques Hugon Claire Paquet |
author_sort |
Frédéric Moynier |
title |
Copper and zinc isotopic excursions in the human brain affected by Alzheimer's disease |
title_short |
Copper and zinc isotopic excursions in the human brain affected by Alzheimer's disease |
title_full |
Copper and zinc isotopic excursions in the human brain affected by Alzheimer's disease |
title_fullStr |
Copper and zinc isotopic excursions in the human brain affected by Alzheimer's disease |
title_full_unstemmed |
Copper and zinc isotopic excursions in the human brain affected by Alzheimer's disease |
title_sort |
copper and zinc isotopic excursions in the human brain affected by alzheimer's disease |
publisher |
Wiley |
series |
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
issn |
2352-8729 |
publishDate |
2020-01-01 |
description |
Abstract Introduction Alzheimer's disease (AD) is neuropathologically marked by amyloid beta (Aβ) plaques and neurofibrillary tangles. Little is known about isotopic compositions of human AD brains. Here we study this in comparison with control subjects for copper and zinc. Methods We use mass‐spectrometry methods, developed to study extraterrestrial materials, to compare the copper and zinc isotopic composition of 10 AD and 10 control brains. Results Copper and zinc natural isotopic compositions of AD brains are statistically different compared to controls, and correlate with Braak stages. Discussion The distribution of natural copper and zinc isotopes in AD is not affected by the diet, but is a consequence of Aβ plaques and tau fibril accumulation. This is well predicted by the changes of the chemical bonding environment caused by the development of Aβ lesions and accumulation of tau proteins. Future work will involve testing whether these changes affect brain functions and are propagated to body fluids. |
topic |
Alzheimer's disease amyloid beta copper isotopes |
url |
https://doi.org/10.1002/dad2.12112 |
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