Antimalarial peroxides
The problem of endemic malaria continues unabated globally. Malaria affects 40 % of the global population, causing an estimated annual mortality of 1.5–2.7 million people. The World Health Organization (WHO) estimates that 90 % of these deaths occur in sub-Saharan Africa among infants under the age...
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Serbian Chemical Society
2009-11-01
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Online Access: | http://www.shd.org.rs/JSCS/Vol74/No11/01-4430_3909.pdf |
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doaj-7ff1defbe5334bed8f23931b3fb130752020-11-25T00:20:01ZengSerbian Chemical Society Journal of the Serbian Chemical Society0352-51392009-11-01741111551193Antimalarial peroxidesDEJAN M. OPSENICABOGDAN A. ŠOLAJAThe problem of endemic malaria continues unabated globally. Malaria affects 40 % of the global population, causing an estimated annual mortality of 1.5–2.7 million people. The World Health Organization (WHO) estimates that 90 % of these deaths occur in sub-Saharan Africa among infants under the age of five. While a vaccine against malaria continues to be elusive, chemotherapy remains the most viable alternative towards treatment of the disease. During last years, the situation has become urgent in many ways, but mainly because of the development of chloroquine-resistant (CQR) strains of Plasmodium falciparum (Pf). The discovery that artemisinin (ART, 1), an active principle of Artemisia annua L., expresses a significant antimalarial activity, especially against CQR strains, opened new approaches for combating malaria. Since the early 1980s, hundreds of semisynthetic and synthetic peroxides have been developed and tested for their antimalarial activity, the results of which were extensively reviewed. In addition, in therapeutic practice, there is no reported case of drug resistance to these antimalarial peroxides. This review summarizes recent achievements in the area of peroxide drug development for malaria chemotherapy.http://www.shd.org.rs/JSCS/Vol74/No11/01-4430_3909.pdfantimalarialperoxidestrioxanestrioxolanestetraoxaneschimeras |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
DEJAN M. OPSENICA BOGDAN A. ŠOLAJA |
spellingShingle |
DEJAN M. OPSENICA BOGDAN A. ŠOLAJA Antimalarial peroxides Journal of the Serbian Chemical Society antimalarial peroxides trioxanes trioxolanes tetraoxanes chimeras |
author_facet |
DEJAN M. OPSENICA BOGDAN A. ŠOLAJA |
author_sort |
DEJAN M. OPSENICA |
title |
Antimalarial peroxides |
title_short |
Antimalarial peroxides |
title_full |
Antimalarial peroxides |
title_fullStr |
Antimalarial peroxides |
title_full_unstemmed |
Antimalarial peroxides |
title_sort |
antimalarial peroxides |
publisher |
Serbian Chemical Society |
series |
Journal of the Serbian Chemical Society |
issn |
0352-5139 |
publishDate |
2009-11-01 |
description |
The problem of endemic malaria continues unabated globally. Malaria affects 40 % of the global population, causing an estimated annual mortality of 1.5–2.7 million people. The World Health Organization (WHO) estimates that 90 % of these deaths occur in sub-Saharan Africa among infants under the age of five. While a vaccine against malaria continues to be elusive, chemotherapy remains the most viable alternative towards treatment of the disease. During last years, the situation has become urgent in many ways, but mainly because of the development of chloroquine-resistant (CQR) strains of Plasmodium falciparum (Pf). The discovery that artemisinin (ART, 1), an active principle of Artemisia annua L., expresses a significant antimalarial activity, especially against CQR strains, opened new approaches for combating malaria. Since the early 1980s, hundreds of semisynthetic and synthetic peroxides have been developed and tested for their antimalarial activity, the results of which were extensively reviewed. In addition, in therapeutic practice, there is no reported case of drug resistance to these antimalarial peroxides. This review summarizes recent achievements in the area of peroxide drug development for malaria chemotherapy. |
topic |
antimalarial peroxides trioxanes trioxolanes tetraoxanes chimeras |
url |
http://www.shd.org.rs/JSCS/Vol74/No11/01-4430_3909.pdf |
work_keys_str_mv |
AT dejanmopsenica antimalarialperoxides AT bogdanasolaja antimalarialperoxides |
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1725369321069215744 |