Effect of 1,5-anhydroglucitol levels on culprit plaque rupture in diabetic patients with acute coronary syndrome
Abstract Background Postprandial hyperglycemia was reported to play a key role in established risk factors of coronary artery diseases (CAD) and cardiovascular events. Serum 1,5-anhydroglucitol (1,5-AG) levels are known to be a clinical marker of short-term postprandial glucose (PPG) excursions. Low...
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doaj-7ff7d19bcf204841a1e5dbbb45c225aa2020-11-25T03:18:26ZengBMCCardiovascular Diabetology1475-28402020-05-0119111010.1186/s12933-020-01045-0Effect of 1,5-anhydroglucitol levels on culprit plaque rupture in diabetic patients with acute coronary syndromeGong Su0Ming-Xi Gao1Gen-Ling Shi2Xi-Xi Dai3Wei-Feng Yao4Tao Zhang5Shao-Wei Zhuang6Department of Cardiovascular Medicine, Shanghai General Hospital Baoshan BranchDepartment of Cardiovascular Medicine, Shanghai General Hospital Baoshan BranchDepartment of Cardiovascular Medicine, Shanghai General Hospital Baoshan BranchDepartment of Cardiovascular Medicine, Shanghai General Hospital Baoshan BranchDepartment of Cardiovascular Medicine, Shanghai General Hospital Baoshan BranchCenter of Cardiology, Beijing Anzhen Hospital, Capital Medical UniversityDepartment of Cardiovascular Medicine, The Seventh People’s Hospital, Shanghai University of Traditional Chinese MedicineAbstract Background Postprandial hyperglycemia was reported to play a key role in established risk factors of coronary artery diseases (CAD) and cardiovascular events. Serum 1,5-anhydroglucitol (1,5-AG) levels are known to be a clinical marker of short-term postprandial glucose (PPG) excursions. Low serum 1,5-AG levels have been associated with occurrence of CAD. However, the relationship between 1,5-AG levels and coronary plaque rupture has not been fully elucidated. The aim of this study was to evaluate 1,5-AG as a predictor of coronary plaque rupture in diabetic patients with acute coronary syndrome (ACS). Methods A total of 144 diabetic patients with ACS were included in this study. All patients underwent intravascular ultrasound examination, which revealed 49 patients with plaque rupture and 95 patients without plaque rupture in the culprit lesion. Fasting blood glucose (FBG), hemoglobin A1c (HbA1c) and 1,5-AG levels were measured before coronary angiography. Fasting urinary 8-iso-prostaglandin F2α (8-iso-PGF2α) level was measured and corrected by creatinine clearance. Results Patients with ruptured plaque had significantly lower serum 1,5-AG levels, longer duration of diabetes, higher HbA1c and FBG levels than patients without ruptured plaque in our study population. In multivariate analysis, low 1,5-AG levels were an independent predictor of plaque rupture (odds ratio 3.421; P = 0.005) in diabetic patients with ACS. The area under the receiver-operating characteristic curve for 1,5-AG (0.658, P = 0.002) to predict plaque rupture was superior to that for HbA1c (0.587, P = 0.087). Levels of 1,5-AG were significantly correlated with urinary 8-iso-prostaglandin F2α levels (r = − 0.234, P = 0.005). Conclusions Serum 1,5-AG may identify high risk for coronary plaque rupture in diabetic patients with ACS, which suggests PPG excursions are related to the pathogenesis of plaque rupture in diabetes.http://link.springer.com/article/10.1186/s12933-020-01045-01,5-AnhydroglucitolPlaque ruptureAcute coronary syndromeDiabetesIntravascular ultrasound |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gong Su Ming-Xi Gao Gen-Ling Shi Xi-Xi Dai Wei-Feng Yao Tao Zhang Shao-Wei Zhuang |
spellingShingle |
Gong Su Ming-Xi Gao Gen-Ling Shi Xi-Xi Dai Wei-Feng Yao Tao Zhang Shao-Wei Zhuang Effect of 1,5-anhydroglucitol levels on culprit plaque rupture in diabetic patients with acute coronary syndrome Cardiovascular Diabetology 1,5-Anhydroglucitol Plaque rupture Acute coronary syndrome Diabetes Intravascular ultrasound |
author_facet |
Gong Su Ming-Xi Gao Gen-Ling Shi Xi-Xi Dai Wei-Feng Yao Tao Zhang Shao-Wei Zhuang |
author_sort |
Gong Su |
title |
Effect of 1,5-anhydroglucitol levels on culprit plaque rupture in diabetic patients with acute coronary syndrome |
title_short |
Effect of 1,5-anhydroglucitol levels on culprit plaque rupture in diabetic patients with acute coronary syndrome |
title_full |
Effect of 1,5-anhydroglucitol levels on culprit plaque rupture in diabetic patients with acute coronary syndrome |
title_fullStr |
Effect of 1,5-anhydroglucitol levels on culprit plaque rupture in diabetic patients with acute coronary syndrome |
title_full_unstemmed |
Effect of 1,5-anhydroglucitol levels on culprit plaque rupture in diabetic patients with acute coronary syndrome |
title_sort |
effect of 1,5-anhydroglucitol levels on culprit plaque rupture in diabetic patients with acute coronary syndrome |
publisher |
BMC |
series |
Cardiovascular Diabetology |
issn |
1475-2840 |
publishDate |
2020-05-01 |
description |
Abstract Background Postprandial hyperglycemia was reported to play a key role in established risk factors of coronary artery diseases (CAD) and cardiovascular events. Serum 1,5-anhydroglucitol (1,5-AG) levels are known to be a clinical marker of short-term postprandial glucose (PPG) excursions. Low serum 1,5-AG levels have been associated with occurrence of CAD. However, the relationship between 1,5-AG levels and coronary plaque rupture has not been fully elucidated. The aim of this study was to evaluate 1,5-AG as a predictor of coronary plaque rupture in diabetic patients with acute coronary syndrome (ACS). Methods A total of 144 diabetic patients with ACS were included in this study. All patients underwent intravascular ultrasound examination, which revealed 49 patients with plaque rupture and 95 patients without plaque rupture in the culprit lesion. Fasting blood glucose (FBG), hemoglobin A1c (HbA1c) and 1,5-AG levels were measured before coronary angiography. Fasting urinary 8-iso-prostaglandin F2α (8-iso-PGF2α) level was measured and corrected by creatinine clearance. Results Patients with ruptured plaque had significantly lower serum 1,5-AG levels, longer duration of diabetes, higher HbA1c and FBG levels than patients without ruptured plaque in our study population. In multivariate analysis, low 1,5-AG levels were an independent predictor of plaque rupture (odds ratio 3.421; P = 0.005) in diabetic patients with ACS. The area under the receiver-operating characteristic curve for 1,5-AG (0.658, P = 0.002) to predict plaque rupture was superior to that for HbA1c (0.587, P = 0.087). Levels of 1,5-AG were significantly correlated with urinary 8-iso-prostaglandin F2α levels (r = − 0.234, P = 0.005). Conclusions Serum 1,5-AG may identify high risk for coronary plaque rupture in diabetic patients with ACS, which suggests PPG excursions are related to the pathogenesis of plaque rupture in diabetes. |
topic |
1,5-Anhydroglucitol Plaque rupture Acute coronary syndrome Diabetes Intravascular ultrasound |
url |
http://link.springer.com/article/10.1186/s12933-020-01045-0 |
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