Rho, ROCK and actomyosin contractility in metastasis as drug targets [version 1; referees: 2 approved]
Metastasis is the spread of cancer cells around the body and the cause of the majority of cancer deaths. Metastasis is a very complex process in which cancer cells need to dramatically modify their cytoskeleton and cope with different environments to successfully colonize a secondary organ. In this...
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doaj-7ff90bb4e0f44b9b8ef0f9da3a91fc472020-11-25T03:06:26ZengF1000 Research LtdF1000Research2046-14022016-04-01510.12688/f1000research.7909.18513Rho, ROCK and actomyosin contractility in metastasis as drug targets [version 1; referees: 2 approved]Irene Rodriguez-Hernandez0Gaia Cantelli1Fanshawe Bruce2Victoria Sanz-Moreno3Tumour Plasticity Laboratory, Randall Division of Cell and Molecular Biophysics, Guy’s Campus, King’s College London, London, SE1 1UL, UKTumour Plasticity Laboratory, Randall Division of Cell and Molecular Biophysics, Guy’s Campus, King’s College London, London, SE1 1UL, UKDepartment of Imaging Chemistry and Biology, Division of Imaging Sciences and Biomedical Engineering, St. Thomas Hospital, King’s College London, London, SE1 7EH, UKTumour Plasticity Laboratory, Randall Division of Cell and Molecular Biophysics, Guy’s Campus, King’s College London, London, SE1 1UL, UKMetastasis is the spread of cancer cells around the body and the cause of the majority of cancer deaths. Metastasis is a very complex process in which cancer cells need to dramatically modify their cytoskeleton and cope with different environments to successfully colonize a secondary organ. In this review, we discuss recent findings pointing at Rho-ROCK or actomyosin force (or both) as major drivers of many of the steps required for metastatic success. We propose that these are important drug targets that need to be considered in the clinic to palliate metastatic disease.http://f1000research.com/articles/5-783/v1Cancer TherapeuticsCell AdhesionCell Growth & DivisionCell SignalingCytoskeletonDrug Discovery & DesignMembranes & Sorting |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Irene Rodriguez-Hernandez Gaia Cantelli Fanshawe Bruce Victoria Sanz-Moreno |
spellingShingle |
Irene Rodriguez-Hernandez Gaia Cantelli Fanshawe Bruce Victoria Sanz-Moreno Rho, ROCK and actomyosin contractility in metastasis as drug targets [version 1; referees: 2 approved] F1000Research Cancer Therapeutics Cell Adhesion Cell Growth & Division Cell Signaling Cytoskeleton Drug Discovery & Design Membranes & Sorting |
author_facet |
Irene Rodriguez-Hernandez Gaia Cantelli Fanshawe Bruce Victoria Sanz-Moreno |
author_sort |
Irene Rodriguez-Hernandez |
title |
Rho, ROCK and actomyosin contractility in metastasis as drug targets [version 1; referees: 2 approved] |
title_short |
Rho, ROCK and actomyosin contractility in metastasis as drug targets [version 1; referees: 2 approved] |
title_full |
Rho, ROCK and actomyosin contractility in metastasis as drug targets [version 1; referees: 2 approved] |
title_fullStr |
Rho, ROCK and actomyosin contractility in metastasis as drug targets [version 1; referees: 2 approved] |
title_full_unstemmed |
Rho, ROCK and actomyosin contractility in metastasis as drug targets [version 1; referees: 2 approved] |
title_sort |
rho, rock and actomyosin contractility in metastasis as drug targets [version 1; referees: 2 approved] |
publisher |
F1000 Research Ltd |
series |
F1000Research |
issn |
2046-1402 |
publishDate |
2016-04-01 |
description |
Metastasis is the spread of cancer cells around the body and the cause of the majority of cancer deaths. Metastasis is a very complex process in which cancer cells need to dramatically modify their cytoskeleton and cope with different environments to successfully colonize a secondary organ. In this review, we discuss recent findings pointing at Rho-ROCK or actomyosin force (or both) as major drivers of many of the steps required for metastatic success. We propose that these are important drug targets that need to be considered in the clinic to palliate metastatic disease. |
topic |
Cancer Therapeutics Cell Adhesion Cell Growth & Division Cell Signaling Cytoskeleton Drug Discovery & Design Membranes & Sorting |
url |
http://f1000research.com/articles/5-783/v1 |
work_keys_str_mv |
AT irenerodriguezhernandez rhorockandactomyosincontractilityinmetastasisasdrugtargetsversion1referees2approved AT gaiacantelli rhorockandactomyosincontractilityinmetastasisasdrugtargetsversion1referees2approved AT fanshawebruce rhorockandactomyosincontractilityinmetastasisasdrugtargetsversion1referees2approved AT victoriasanzmoreno rhorockandactomyosincontractilityinmetastasisasdrugtargetsversion1referees2approved |
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