Psoriasis and Mental Health Workshop Report: Exploring the Links between Psychosocial Factors, Psoriasis, Neuroinflammation and Cardiovascular Disease Risk
Psoriasis is a systemic, relapsing, inflammatory disease associated with serious comorbidities including mood problems and/or unhealthy lifestyle behaviours. Cutaneous and systemic abnormalities in innate and acquired immunity play a role in its pathogenesis. The exact pathogenetic mechanism remains...
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https://www.medicaljournals.se/jadv/content/html/10.2340/00015555-3375
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doaj-7ffb07d064d74ebdb877c4cfc0d447992020-11-25T01:20:44ZengSociety for Publication of Acta Dermato-VenereologicaActa Dermato-Venereologica0001-55551651-20572020-01-011001adv0002010.2340/00015555-33755639Psoriasis and Mental Health Workshop Report: Exploring the Links between Psychosocial Factors, Psoriasis, Neuroinflammation and Cardiovascular Disease RiskC. Elise Kleyn0Peter S. TalbotNehal N. MehtaFrancesca SampognaChris BundyDarren M. AshcroftAlexa B. KimballPeter C.M. van de KerkhofChristopher E.M. GriffithsFernando ValenzuelaJoelle M. van der WaltTsion AberraLluís Puig Dermatology Centre, Salford Royal NHS Foundation Trust, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom. Psoriasis is a systemic, relapsing, inflammatory disease associated with serious comorbidities including mood problems and/or unhealthy lifestyle behaviours. Cutaneous and systemic abnormalities in innate and acquired immunity play a role in its pathogenesis. The exact pathogenetic mechanism remains elusive. Evidence is accumulating that TNF-alpha, IL-17 and IL-23 signalling are highly relevant as targeting these pathways reduces disease activity. Evidence suggests a strong link between psoriasis and depression in adults. The International Psoriasis Council (IPC) held a roundtable event, “Psoriasis and Mental Health”, in Barcelona, Spain which focused on the presence of depression and suicidality, plus the role of neuroinflammation in psoriasis, sleep disruption and the impact of depression on cardiovascular disease outcomes. We summarize here the expert presentations to provide additional insight into the understanding of psychiatric comorbidities of psoriasis and of the impact of chronic, systemic inflammation on neuro- and cardiovascular outcomes. the associations between psoriasis and other psychiatric comorbidities are still controversial and warrant further attention. https://www.medicaljournals.se/jadv/content/html/10.2340/00015555-3375 psoriasis depression cardiovascular mental health sleep neuroinflammation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
C. Elise Kleyn Peter S. Talbot Nehal N. Mehta Francesca Sampogna Chris Bundy Darren M. Ashcroft Alexa B. Kimball Peter C.M. van de Kerkhof Christopher E.M. Griffiths Fernando Valenzuela Joelle M. van der Walt Tsion Aberra Lluís Puig |
spellingShingle |
C. Elise Kleyn Peter S. Talbot Nehal N. Mehta Francesca Sampogna Chris Bundy Darren M. Ashcroft Alexa B. Kimball Peter C.M. van de Kerkhof Christopher E.M. Griffiths Fernando Valenzuela Joelle M. van der Walt Tsion Aberra Lluís Puig Psoriasis and Mental Health Workshop Report: Exploring the Links between Psychosocial Factors, Psoriasis, Neuroinflammation and Cardiovascular Disease Risk Acta Dermato-Venereologica psoriasis depression cardiovascular mental health sleep neuroinflammation |
author_facet |
C. Elise Kleyn Peter S. Talbot Nehal N. Mehta Francesca Sampogna Chris Bundy Darren M. Ashcroft Alexa B. Kimball Peter C.M. van de Kerkhof Christopher E.M. Griffiths Fernando Valenzuela Joelle M. van der Walt Tsion Aberra Lluís Puig |
author_sort |
C. Elise Kleyn |
title |
Psoriasis and Mental Health Workshop Report: Exploring the Links between Psychosocial Factors, Psoriasis, Neuroinflammation and Cardiovascular Disease Risk |
title_short |
Psoriasis and Mental Health Workshop Report: Exploring the Links between Psychosocial Factors, Psoriasis, Neuroinflammation and Cardiovascular Disease Risk |
title_full |
Psoriasis and Mental Health Workshop Report: Exploring the Links between Psychosocial Factors, Psoriasis, Neuroinflammation and Cardiovascular Disease Risk |
title_fullStr |
Psoriasis and Mental Health Workshop Report: Exploring the Links between Psychosocial Factors, Psoriasis, Neuroinflammation and Cardiovascular Disease Risk |
title_full_unstemmed |
Psoriasis and Mental Health Workshop Report: Exploring the Links between Psychosocial Factors, Psoriasis, Neuroinflammation and Cardiovascular Disease Risk |
title_sort |
psoriasis and mental health workshop report: exploring the links between psychosocial factors, psoriasis, neuroinflammation and cardiovascular disease risk |
publisher |
Society for Publication of Acta Dermato-Venereologica |
series |
Acta Dermato-Venereologica |
issn |
0001-5555 1651-2057 |
publishDate |
2020-01-01 |
description |
Psoriasis is a systemic, relapsing, inflammatory disease associated with serious comorbidities including mood problems and/or unhealthy lifestyle behaviours. Cutaneous and systemic abnormalities in innate and acquired immunity play a role in its pathogenesis. The exact pathogenetic mechanism remains elusive. Evidence is accumulating that TNF-alpha, IL-17 and IL-23 signalling are highly relevant as targeting these pathways reduces disease activity. Evidence suggests a strong link between psoriasis and depression in adults. The International Psoriasis Council (IPC) held a roundtable event, “Psoriasis and Mental Health”, in Barcelona, Spain which focused on the presence of depression and suicidality, plus the role of neuroinflammation in psoriasis, sleep disruption and the impact of depression on cardiovascular disease outcomes. We summarize here the expert presentations to provide additional insight into the understanding of psychiatric comorbidities of psoriasis and of the impact of chronic, systemic inflammation on neuro- and cardiovascular outcomes. the associations between psoriasis and other psychiatric comorbidities are still controversial and warrant further attention. |
topic |
psoriasis depression cardiovascular mental health sleep neuroinflammation |
url |
https://www.medicaljournals.se/jadv/content/html/10.2340/00015555-3375
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work_keys_str_mv |
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