Psoriasis and Mental Health Workshop Report: Exploring the Links between Psychosocial Factors, Psoriasis, Neuroinflammation and Cardiovascular Disease Risk

• Main Authors: C. Elise Kleyn, Peter S. Talbot, Nehal N. Mehta, Francesca Sampogna, Chris Bundy, Darren M. Ashcroft, Alexa B. Kimball, Peter C.M. van de Kerkhof, Christopher E.M. Griffiths, Fernando Valenzuela, Joelle M. van der Walt, Tsion Aberra, Lluís Puig
• Format: Article
• Language: English
• Published: Society for Publication of Acta Dermato-Venereologica 2020-01-01
• Series: Acta Dermato-Venereologica
• Subjects: psoriasis; depression; cardiovascular mental health; sleep; neuroinflammation
• Online Access: https://www.medicaljournals.se/jadv/content/html/10.2340/00015555-3375

Psoriasis is a systemic, relapsing, inflammatory disease associated with serious comorbidities including mood problems and/or unhealthy lifestyle behaviours. Cutaneous and systemic abnormalities in innate and acquired immunity play a role in its pathogenesis. The exact pathogenetic mechanism remains elusive. Evidence is accumulating that TNF-alpha, IL-17 and IL-23 signalling are highly relevant as targeting these pathways reduces disease activity. Evidence suggests a strong link between psoriasis and depression in adults. The International Psoriasis Council (IPC) held a roundtable event, “Psoriasis and Mental Health”, in Barcelona, Spain which focused on the presence of depression and suicidality, plus the role of neuroinflammation in psoriasis, sleep disruption and the impact of depression on cardiovascular disease outcomes. We summarize here the expert presentations to provide additional insight into the understanding of psychiatric comorbidities of psoriasis and of the impact of chronic, systemic inflammation on neuro- and cardiovascular outcomes. the associations between psoriasis and other psychiatric comorbidities are still controversial and warrant further attention.