Intraganglionic AAV6 results in efficient and long-term gene transfer to peripheral sensory nervous system in adult rats.

Intraganglionic AAV6 results in efficient and long-term gene transfer to peripheral sensory nervous system in adult rats.

We previously demonstrated safe and reliable gene transfer to the dorsal root ganglion (DRG) using a direct microinjection procedure to deliver recombinant adeno-associated virus (AAV) vector. In this study, we proceed to compare the in vivo transduction patterns of self-complementary (sc) AAV6 and...

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Bibliographic Details
Main Authors: Hongwei Yu, Gregory Fischer, Lejla Ferhatovic, Fan Fan, Alan R Light, Dorothee Weihrauch, Damir Sapunar, Hiroyuki Nakai, Frank Park, Quinn H Hogan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3628918?pdf=render

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