Ranking genomic features using an information-theoretic measure of epigenetic discordance

Ranking genomic features using an information-theoretic measure of epigenetic discordance

Abstract Background Establishment and maintenance of DNA methylation throughout the genome is an important epigenetic mechanism that regulates gene expression whose disruption has been implicated in human diseases like cancer. It is therefore crucial to know which genes, or other genomic features of...

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Bibliographic Details
Main Authors: Garrett Jenkinson, Jordi Abante, Michael A. Koldobskiy, Andrew P. Feinberg, John Goutsias
Format: Article
Language:English
Published: BMC 2019-04-01
Series:BMC Bioinformatics
Subjects:
DNA methylation
Genomic feature analysis
Information theory
Mutual Information
Gene ranking
Methylation analysis
Online Access:http://link.springer.com/article/10.1186/s12859-019-2777-6

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