Distinct mechanisms of axonal globule formation in mice expressing human wild type α-synuclein or dementia with Lewy bodies-linked P123H ß-synuclein

Distinct mechanisms of axonal globule formation in mice expressing human wild type α-synuclein or dementia with Lewy bodies-linked P123H ß-synuclein

<p>Abstract</p> <p>Background</p> <p>Axonopathy is critical in the early pathogenesis of neurodegenerative diseases, including Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). Axonal swellings such as globules and spheroids are a distinct feature of axonopa...

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Bibliographic Details
Main Authors: Sekigawa Akio, Fujita Masayo, Sekiyama Kazunari, Takamatsu Yoshiki, Hatano Taku, Rockenstein Edward, La Spada Albert R, Masliah Eliezer, Hashimoto Makoto
Format: Article
Language:English
Published: BMC 2012-09-01
Series:Molecular Brain
Subjects:
α-synuclein
P123H β-synuclein
Parkinson’s disease
Mitochondria
Lysosome
Transgenic mouse
Online Access:http://www.molecularbrain.com/content/5/1/34

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