Impact of BAFF Blockade on Inflammation, Germinal Center Reaction and Effector B-Cells During Acute SIV Infection

Impact of BAFF Blockade on Inflammation, Germinal Center Reaction and Effector B-Cells During Acute SIV Infection

Memory B-cell dysfunctions and inefficient antibody response suggest germinal center (GC) impairments during HIV/SIV infection with possible contribution of overproduced B-cell activating factor (BAFF). To address this question, we compared proportions and functions of various B-cell subsets and fol...

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Bibliographic Details
Main Authors: Gwenoline Borhis, Maria Trovato, Hany M. Ibrahim, Stephane Isnard, Roger Le Grand, Nathalie Bosquet, Yolande Richard
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Immunology
Subjects:
B-cells
BAFF
GC
TFH
memory B-cells
SIV
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00252/full

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