Diffuse Large B-Cell Lymphoma of Maxilla – A Case Report of Late Relapse
Diffuse Large B Cell Lymphomas (DLBCL) encompasses a heterogeneous group of tumors that together constitute the commonest of all Non Hodgkin Lymphoma (NHL) and the proclivity of DLBCL to oral cavity is unknown. They mostly arise from soft tissues as asymptomatic lesions, mostly without ‘B’ symptom...
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doaj-8029eac007b74008b94f8ea9ab5692d62020-11-25T03:11:52ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2016-04-01104ZD12ZD1410.7860/JCDR/2016/16139.7695Diffuse Large B-Cell Lymphoma of Maxilla – A Case Report of Late RelapseMedikonda Suresh Kumar0Ashalata Gannepalli1Anuradha Chandragiri2Konda Amarnath3Professor and Head of Deparment, Department of Oral and Maxillofacial Surgery, Meghana Institute of Dental Sciences, Nizamabad, Telangana, India.Professor, Department of Oral Maxillofacial Pathology and Microbiology, Panineeya Mahavidyalaya Institute of Dental Sciences and Research Centre, Hyderabad, Telangana, India.Post-graduate Student, Department of Oral Maxillofacial Pathology and Microbiology, Panineeya Mahavidyalaya Institute of Dental Sciences and Research Centre, Hyderabad, Telangana, India.Reader, Department of Oral and Maxillofacial Surgery, Meghana Institute of Dental Sciences, Nizamabad, Telangana, India.Diffuse Large B Cell Lymphomas (DLBCL) encompasses a heterogeneous group of tumors that together constitute the commonest of all Non Hodgkin Lymphoma (NHL) and the proclivity of DLBCL to oral cavity is unknown. They mostly arise from soft tissues as asymptomatic lesions, mostly without ‘B’ symptoms and involvement of jaw bones is uncommon. Most studies and case reports of oral DLBCL’s are based on, manifestation of primary extra-nodal disease or a component of a disseminated disease process involving regional lymph nodes. Many investigators have proposed that patients with this cell type who maintain a complete response for 24 consecutive months are cured because late relapses seldom occur. With advances in treatment modalities, many patients with NHL become long-term survivors and the risk of relapses or second tumors are of growing concern. We present a case of DLBCL which relapsed after five years of initial lesion in a 41 year old female patient and presented as a nonspecific bilateral anterior maxillary radiolucency. DLBCL usually express pan-B markers with small percentage expressing T-cell markers. Few rare cases of DLBCL have shown CD3 expression, which is a most sensitive T-cell marker which was focally expressed in the present case.https://jcdr.net/articles/PDF/7695/16139_CE(EK)_F(AK)_PF1(EKAK)_PFA(NC_AK)_PFA2(HNAK)_PF3(PRO).pdfimmunohistochemistryintrabonynon-hodgkin’s lymphomaradiolucencyswelling |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Medikonda Suresh Kumar Ashalata Gannepalli Anuradha Chandragiri Konda Amarnath |
spellingShingle |
Medikonda Suresh Kumar Ashalata Gannepalli Anuradha Chandragiri Konda Amarnath Diffuse Large B-Cell Lymphoma of Maxilla – A Case Report of Late Relapse Journal of Clinical and Diagnostic Research immunohistochemistry intrabony non-hodgkin’s lymphoma radiolucency swelling |
author_facet |
Medikonda Suresh Kumar Ashalata Gannepalli Anuradha Chandragiri Konda Amarnath |
author_sort |
Medikonda Suresh Kumar |
title |
Diffuse Large B-Cell Lymphoma of Maxilla – A Case Report of Late Relapse |
title_short |
Diffuse Large B-Cell Lymphoma of Maxilla – A Case Report of Late Relapse |
title_full |
Diffuse Large B-Cell Lymphoma of Maxilla – A Case Report of Late Relapse |
title_fullStr |
Diffuse Large B-Cell Lymphoma of Maxilla – A Case Report of Late Relapse |
title_full_unstemmed |
Diffuse Large B-Cell Lymphoma of Maxilla – A Case Report of Late Relapse |
title_sort |
diffuse large b-cell lymphoma of maxilla – a case report of late relapse |
publisher |
JCDR Research and Publications Private Limited |
series |
Journal of Clinical and Diagnostic Research |
issn |
2249-782X 0973-709X |
publishDate |
2016-04-01 |
description |
Diffuse Large B Cell Lymphomas (DLBCL) encompasses a heterogeneous group of tumors that together constitute the commonest of all
Non Hodgkin Lymphoma (NHL) and the proclivity of DLBCL to oral cavity is unknown. They mostly arise from soft tissues as asymptomatic
lesions, mostly without ‘B’ symptoms and involvement of jaw bones is uncommon. Most studies and case reports of oral DLBCL’s are
based on, manifestation of primary extra-nodal disease or a component of a disseminated disease process involving regional lymph
nodes. Many investigators have proposed that patients with this cell type who maintain a complete response for 24 consecutive months
are cured because late relapses seldom occur. With advances in treatment modalities, many patients with NHL become long-term
survivors and the risk of relapses or second tumors are of growing concern. We present a case of DLBCL which relapsed after five years
of initial lesion in a 41 year old female patient and presented as a nonspecific bilateral anterior maxillary radiolucency. DLBCL usually
express pan-B markers with small percentage expressing T-cell markers. Few rare cases of DLBCL have shown CD3 expression, which
is a most sensitive T-cell marker which was focally expressed in the present case. |
topic |
immunohistochemistry intrabony non-hodgkin’s lymphoma radiolucency swelling |
url |
https://jcdr.net/articles/PDF/7695/16139_CE(EK)_F(AK)_PF1(EKAK)_PFA(NC_AK)_PFA2(HNAK)_PF3(PRO).pdf |
work_keys_str_mv |
AT medikondasureshkumar diffuselargebcelllymphomaofmaxillaacasereportoflaterelapse AT ashalatagannepalli diffuselargebcelllymphomaofmaxillaacasereportoflaterelapse AT anuradhachandragiri diffuselargebcelllymphomaofmaxillaacasereportoflaterelapse AT kondaamarnath diffuselargebcelllymphomaofmaxillaacasereportoflaterelapse |
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1724652494292779008 |