Anti-ferroptotic mechanism of IL4i1-mediated amino acid metabolism

Anti-ferroptotic mechanism of IL4i1-mediated amino acid metabolism

Interleukin-4-induced-1 (IL4i1) is an amino acid oxidase secreted from immune cells. Recent observations have suggested that IL4i1 is pro-tumorigenic via unknown mechanisms. As IL4i1 has homologs in snake venoms (L-amino acid oxidases [LAAO]), we used comparative approaches to gain insight into the...

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Bibliographic Details
Main Authors: Leonie Zeitler, Alessandra Fiore, Claudia Meyer, Marion Russier, Gaia Zanella, Sabine Suppmann, Marco Gargaro, Sachdev S Sidhu, Somasekar Seshagiri, Caspar Ohnmacht, Thomas Köcher, Francesca Fallarino, Andreas Linkermann, Peter J Murray
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-03-01
Series:eLife
Subjects:
tryptophan
venom
ferroptosis
cell death
hydrogen peroxide
Online Access:https://elifesciences.org/articles/64806

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