Sirt1 Activity in the Brain: Simultaneous Effects on Energy Homeostasis and Reproduction

Diet deeply impacts brain functions like synaptic plasticity and cognitive processes, neuroendocrine functions, reproduction and behaviour, with detrimental or protective effects on neuronal physiology and therefore consequences for health. In this respect, the activity of metabolic sensors within t...

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Main Authors:	Stefania D’Angelo, Elena Mele, Federico Di Filippo, Andrea Viggiano, Rosaria Meccariello
Format:	Article
Language:	English
Published:	MDPI AG 2021-01-01
Series:	International Journal of Environmental Research and Public Health
Subjects:	Sirt1 brain energy homeostasis reproduction kisspeptin polyphenols
Online Access:	https://www.mdpi.com/1660-4601/18/3/1243

id	doaj-802d8cd4582e47afafa8bd29f0d2beff
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spelling	doaj-802d8cd4582e47afafa8bd29f0d2beff2021-01-31T00:02:24ZengMDPI AGInternational Journal of Environmental Research and Public Health1661-78271660-46012021-01-01181243124310.3390/ijerph18031243Sirt1 Activity in the Brain: Simultaneous Effects on Energy Homeostasis and ReproductionStefania D’Angelo0Elena Mele1Federico Di Filippo2Andrea Viggiano3Rosaria Meccariello4Department of Movement Sciences and Wellbeing, University of Naples Parthenope, 80133 Napoli, ItalyDepartment of Movement Sciences and Wellbeing, University of Naples Parthenope, 80133 Napoli, ItalyDeptartment of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, via Allende, 84081 Baronissi (SA), ItalyDeptartment of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, via Allende, 84081 Baronissi (SA), ItalyDepartment of Movement Sciences and Wellbeing, University of Naples Parthenope, 80133 Napoli, ItalyDiet deeply impacts brain functions like synaptic plasticity and cognitive processes, neuroendocrine functions, reproduction and behaviour, with detrimental or protective effects on neuronal physiology and therefore consequences for health. In this respect, the activity of metabolic sensors within the brain is critical for the maintenance of health status and represents a possible therapeutic target for some diseases. This review summarizes the main activity of Sirtuin1 (Sirt1), a metabolic sensor within the brain with a focus on the link between the central control of energy homeostasis and reproduction. The possible modulation of Sirt1 by natural phytochemical compounds like polyphenols is also discussed.https://www.mdpi.com/1660-4601/18/3/1243Sirt1brainenergy homeostasisreproductionkisspeptinpolyphenols
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Stefania D’Angelo Elena Mele Federico Di Filippo Andrea Viggiano Rosaria Meccariello
spellingShingle	Stefania D’Angelo Elena Mele Federico Di Filippo Andrea Viggiano Rosaria Meccariello Sirt1 Activity in the Brain: Simultaneous Effects on Energy Homeostasis and Reproduction International Journal of Environmental Research and Public Health Sirt1 brain energy homeostasis reproduction kisspeptin polyphenols
author_facet	Stefania D’Angelo Elena Mele Federico Di Filippo Andrea Viggiano Rosaria Meccariello
author_sort	Stefania D’Angelo
title	Sirt1 Activity in the Brain: Simultaneous Effects on Energy Homeostasis and Reproduction
title_short	Sirt1 Activity in the Brain: Simultaneous Effects on Energy Homeostasis and Reproduction
title_full	Sirt1 Activity in the Brain: Simultaneous Effects on Energy Homeostasis and Reproduction
title_fullStr	Sirt1 Activity in the Brain: Simultaneous Effects on Energy Homeostasis and Reproduction
title_full_unstemmed	Sirt1 Activity in the Brain: Simultaneous Effects on Energy Homeostasis and Reproduction
title_sort	sirt1 activity in the brain: simultaneous effects on energy homeostasis and reproduction
publisher	MDPI AG
series	International Journal of Environmental Research and Public Health
issn	1661-7827 1660-4601
publishDate	2021-01-01
description	Diet deeply impacts brain functions like synaptic plasticity and cognitive processes, neuroendocrine functions, reproduction and behaviour, with detrimental or protective effects on neuronal physiology and therefore consequences for health. In this respect, the activity of metabolic sensors within the brain is critical for the maintenance of health status and represents a possible therapeutic target for some diseases. This review summarizes the main activity of Sirtuin1 (Sirt1), a metabolic sensor within the brain with a focus on the link between the central control of energy homeostasis and reproduction. The possible modulation of Sirt1 by natural phytochemical compounds like polyphenols is also discussed.
topic	Sirt1 brain energy homeostasis reproduction kisspeptin polyphenols
url	https://www.mdpi.com/1660-4601/18/3/1243
work_keys_str_mv	AT stefaniadangelo sirt1activityinthebrainsimultaneouseffectsonenergyhomeostasisandreproduction AT elenamele sirt1activityinthebrainsimultaneouseffectsonenergyhomeostasisandreproduction AT federicodifilippo sirt1activityinthebrainsimultaneouseffectsonenergyhomeostasisandreproduction AT andreaviggiano sirt1activityinthebrainsimultaneouseffectsonenergyhomeostasisandreproduction AT rosariameccariello sirt1activityinthebrainsimultaneouseffectsonenergyhomeostasisandreproduction
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Sirt1 Activity in the Brain: Simultaneous Effects on Energy Homeostasis and Reproduction

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