| Summary: | : Background: As a rare cause of unilateral leg swelling, extrinsic vein compression caused by intraperitoneal, retroperitoneal, or inguinal lesions has been noted. A rare case of leg swelling as a cause of extrinsic compression of common femoral vein from a ganglion cyst in the groin is presented. Case presentation: A 38 year old man was referred with a 3 week history of left leg swelling. Following a radiological diagnosis of common femoral vein compression from a cystic groin mass, he firstly underwent needle aspiration. Although the lesion became somewhat smaller, his left leg was still swollen, and he underwent surgical excision of the lesion 2 days after needle aspiration. Histopathological features of the cystic wall were consistent with those of a ganglion cyst. He was discharged from the hospital with complete improvement of the leg swelling, and has remained free from recurrence 1 year after surgery. Conclusion: Femoral vein compression by a ganglion cyst in the groin is a very rare pathology; however, it should be kept in mind in the differential diagnosis of unilateral leg swelling. Keywords: Femoral vein compression, Groin ganglion, Unilateral leg swelling
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