A comparison of azacitidine and decitabine activities in acute myeloid leukemia cell lines.

A comparison of azacitidine and decitabine activities in acute myeloid leukemia cell lines.

BACKGROUND: The cytidine nucleoside analogs azacitidine (AZA) and decitabine (DAC) are used for the treatment of patients with myelodysplastic syndromes and acute myeloid leukemia (AML). Few non-clinical studies have directly compared the mechanisms of action of these agents in a head-to-head fashio...

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Bibliographic Details
Main Authors: Paul W Hollenbach, Aaron N Nguyen, Helen Brady, Michelle Williams, Yuhong Ning, Normand Richard, Leslie Krushel, Sharon L Aukerman, Carla Heise, Kyle J MacBeth
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2814859?pdf=render

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