REGULATION AND INTENSIFICATION WAYS OF LYSINE BIOSYNTHESIS

• Main Authors: Г. С. Андріяш, Г. М. Заболотна, С. М. Шульга
• Format: Article
• Language: English
• Published: Odessa I. I. Mechnikov National University 2012-12-01
• Series: Mìkrobìologìâ ì Bìotehnologìâ
• Subjects: ауксотрофність; біосинтез; інтенсифікація; лізин; продуцент.
• Online Access: http://mbt.onu.edu.ua/article/view/90435

There were analysed in the review the ways of intensification of the microbiological synthesis of lysine, used in the production of food, feed and pharmaceutical industries. The biochemical synthesis scheme of lysine by bacteria through diaminopymelat and its regulation was examined. It was shown that increased synthesis of amino acids in microorganisms was associated with specific mutation disruption of regulatory control of biosynthesis. The technological ways of improvement of lysine biosynthesis were represented. It was shown lysine biosynthesis reached the level of 30–50 g/dm3 due to the technological methods and mutant strains in combination with the biotechnological techniques produced 50–70 g/dm3 and provided 40% conversion of the amino acid substrate