Translation and codon usage regulate Argonaute slicer activity to trigger small RNA biogenesis

22G-RNAs are single-stranded antisense small RNAs that are expressed in C. elegans germline. Here the authors show that CSR-1 dependent 22G-RNAs are produced in the cytosol on mRNAs actively engaged in translation and that codon usage of an mRNA regulates the biogenesis of CSR-1 dependent 22G-RNAs.

Bibliographic Details
Main Authors:	Meetali Singh, Eric Cornes, Blaise Li, Piergiuseppe Quarato, Loan Bourdon, Florent Dingli, Damarys Loew, Simone Proccacia, Germano Cecere
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-06-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-23615-w

id	doaj-803ff8b52d0a47a39490fc9e92339e3c
record_format	Article
spelling	doaj-803ff8b52d0a47a39490fc9e92339e3c2021-06-13T11:15:49ZengNature Publishing GroupNature Communications2041-17232021-06-0112111810.1038/s41467-021-23615-wTranslation and codon usage regulate Argonaute slicer activity to trigger small RNA biogenesisMeetali Singh0Eric Cornes1Blaise Li2Piergiuseppe Quarato3Loan Bourdon4Florent Dingli5Damarys Loew6Simone Proccacia7Germano Cecere8Mechanisms of Epigenetic Inheritance, Department of Developmental and Stem Cell Biology, Institut Pasteur, UMR3738, CNRSMechanisms of Epigenetic Inheritance, Department of Developmental and Stem Cell Biology, Institut Pasteur, UMR3738, CNRSMechanisms of Epigenetic Inheritance, Department of Developmental and Stem Cell Biology, Institut Pasteur, UMR3738, CNRSMechanisms of Epigenetic Inheritance, Department of Developmental and Stem Cell Biology, Institut Pasteur, UMR3738, CNRSMechanisms of Epigenetic Inheritance, Department of Developmental and Stem Cell Biology, Institut Pasteur, UMR3738, CNRSInstitut Curie, PSL Research University, Centre de Recherche, Laboratoire de Spectrométrie de Masse ProtéomiqueInstitut Curie, PSL Research University, Centre de Recherche, Laboratoire de Spectrométrie de Masse ProtéomiqueMechanisms of Epigenetic Inheritance, Department of Developmental and Stem Cell Biology, Institut Pasteur, UMR3738, CNRSMechanisms of Epigenetic Inheritance, Department of Developmental and Stem Cell Biology, Institut Pasteur, UMR3738, CNRS22G-RNAs are single-stranded antisense small RNAs that are expressed in C. elegans germline. Here the authors show that CSR-1 dependent 22G-RNAs are produced in the cytosol on mRNAs actively engaged in translation and that codon usage of an mRNA regulates the biogenesis of CSR-1 dependent 22G-RNAs.https://doi.org/10.1038/s41467-021-23615-w
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Meetali Singh Eric Cornes Blaise Li Piergiuseppe Quarato Loan Bourdon Florent Dingli Damarys Loew Simone Proccacia Germano Cecere
spellingShingle	Meetali Singh Eric Cornes Blaise Li Piergiuseppe Quarato Loan Bourdon Florent Dingli Damarys Loew Simone Proccacia Germano Cecere Translation and codon usage regulate Argonaute slicer activity to trigger small RNA biogenesis Nature Communications
author_facet	Meetali Singh Eric Cornes Blaise Li Piergiuseppe Quarato Loan Bourdon Florent Dingli Damarys Loew Simone Proccacia Germano Cecere
author_sort	Meetali Singh
title	Translation and codon usage regulate Argonaute slicer activity to trigger small RNA biogenesis
title_short	Translation and codon usage regulate Argonaute slicer activity to trigger small RNA biogenesis
title_full	Translation and codon usage regulate Argonaute slicer activity to trigger small RNA biogenesis
title_fullStr	Translation and codon usage regulate Argonaute slicer activity to trigger small RNA biogenesis
title_full_unstemmed	Translation and codon usage regulate Argonaute slicer activity to trigger small RNA biogenesis
title_sort	translation and codon usage regulate argonaute slicer activity to trigger small rna biogenesis
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-06-01
description	22G-RNAs are single-stranded antisense small RNAs that are expressed in C. elegans germline. Here the authors show that CSR-1 dependent 22G-RNAs are produced in the cytosol on mRNAs actively engaged in translation and that codon usage of an mRNA regulates the biogenesis of CSR-1 dependent 22G-RNAs.
url	https://doi.org/10.1038/s41467-021-23615-w
work_keys_str_mv	AT meetalisingh translationandcodonusageregulateargonautesliceractivitytotriggersmallrnabiogenesis AT ericcornes translationandcodonusageregulateargonautesliceractivitytotriggersmallrnabiogenesis AT blaiseli translationandcodonusageregulateargonautesliceractivitytotriggersmallrnabiogenesis AT piergiuseppequarato translationandcodonusageregulateargonautesliceractivitytotriggersmallrnabiogenesis AT loanbourdon translationandcodonusageregulateargonautesliceractivitytotriggersmallrnabiogenesis AT florentdingli translationandcodonusageregulateargonautesliceractivitytotriggersmallrnabiogenesis AT damarysloew translationandcodonusageregulateargonautesliceractivitytotriggersmallrnabiogenesis AT simoneproccacia translationandcodonusageregulateargonautesliceractivitytotriggersmallrnabiogenesis AT germanocecere translationandcodonusageregulateargonautesliceractivitytotriggersmallrnabiogenesis
_version_	1721380030459674624

Translation and codon usage regulate Argonaute slicer activity to trigger small RNA biogenesis

Similar Items