Construction and Immunogenicity of Modified mRNA-Vaccine Variants Encoding Influenza Virus Antigens

Construction and Immunogenicity of Modified mRNA-Vaccine Variants Encoding Influenza Virus Antigens

Nucleic acid-based influenza vaccines are a promising platform that have recently and rapidly developed. We previously demonstrated the immunogenicity of DNA vaccines encoding artificial immunogens AgH1, AgH3, and AgM2, which contained conserved fragments of the hemagglutinin stem of two subtypes of...

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Bibliographic Details
Main Authors: Ekaterina V. Starostina, Sergei V. Sharabrin, Denis N. Antropov, Grigory A. Stepanov, Georgiy Yu. Shevelev, Anna E. Lemza, Andrey P. Rudometov, Mariya B. Borgoyakova, Nadezhda B. Rudometova, Vasiliy Yu. Marchenko, Natalia V. Danilchenko, Anton N. Chikaev, Sergei I. Bazhan, Alexander A. Ilyichev, Larisa I. Karpenko
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Vaccines
Subjects:
mRNA-vaccine
influenza virus
mRNA modification
Anti-Reverse Cap Analog
pseudouridine
N6-methyladenosine
Online Access:https://www.mdpi.com/2076-393X/9/5/452

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